COMPARISON OF LAL TEST WITH THE RABBIT PYROGEN TEST

LAL 测试与兔子热原测试的比较

• 批准号: 6101322
• 负责人: H D HOCHSTEIN
• 金额: --
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6101322
• 关键词: bioassay; biological products; chemical standardization; drug quality /standard; endotoxins; horseshoe crabs; laboratory rabbit; phagocytes; pyrogens

This is an in vitro testing and date gathering exercise. The rabbit pyrogen test is the classical test for endotoxin. However, the in vitro Limulus Amebocyte Lysate (LAL) test is gradually replacing the rabbit. The LAL test besides being more specific for endotoxin than the rabbit it is also more quantitative. We are gathering data on biological products. It is our intention that over 90% of the products now being tested in rabbits will (in less than a year) be converted to the LAL test.

这是一项体外测试和数据收集练习。兔子 热原检查是经典的内毒素检查方法。然而，体外培养 凝胶溶解试验(LAL)正逐步取代兔。 LAL试验除了对内毒素比兔子更具特异性外 也更加量化。我们正在收集有关生物制品的数据。 我们的意图是，目前正在进行测试的产品中有90%以上 兔子将(在不到一年的时间内)转换为LAL测试。