Detection of Melanoma by Mesoscopic Spectral Imaging

描述：(申请人提供)在家族性黑色素瘤的背景下， 包括大约10%的黑色素瘤总发病率， 非典型痣与近100%的发病风险有关。 70岁前患上原发黑色素瘤。然而，非典型痣也发生在 家族性黑色素瘤背景下，估计散发性的40%-60% 黑色素瘤由这些黑素细胞前体病变发展而来。在患有 家族性黑色素瘤和/或发育不良内脏综合征(DNS)，同样，在 有散发性黑色素瘤和大量不典型黑色素瘤的患者 黑色素痣、原位黑色素瘤和放射状生长期黑色素瘤通常 与不典型的中性粒细胞病变密切相关。目前， 防止非典型痣进展为黑色素瘤的唯一方法是 坚持不懈地监测并在形状变化的最早迹象中切除它们， 大小和/或色素沉着。然而，用眼睛或用 手持白炽灯光源，正如在大多数临床环境中所做的那样，是 既不是有效也不可靠的检测黑色素瘤的方法 毗邻非典型痣。鉴于黑色素瘤发病率的上升 在世界范围内，目前关于早期发现黑色素瘤的限制 与这样的观察并列，即病人通常通过宽而深的 在黑色素瘤的早期阶段切除，显然需要 实施新的诊断设备和技术，可以无创地 并在第一次表现时可重复捕获非典型痣中的黑色素瘤，即 在切除和组织学分析之前。 专注于光学成像作为解决这一需求的一种手段，我们之前 进行了一项研究，首次提供了宏观光谱的证据 成像技术能够在体内检测黑素细胞中出现的黑色素瘤。 前驱病变。基于这一发现，我们现在想要把这个 再投影一步，确定新设计的声光 基于可调谐滤光片(AOTF)的介观光谱成像设备可以建立 发生在黑色素瘤或与其相邻的黑色素瘤的光谱特征 不典型的痣。

DESCRIPTION: (provided by applicant) In the setting of familial melanoma, comprising about 10 percent overall incidence of melanoma, the presence of atypical nevi is associated with a nearly 100 percent risk of developing primary melanoma by age 70. However, atypical nevi also occur outside the familial melanoma setting, and it is estimated that 40-60 percent of sporadic melanomas develop from these melanocytic precursor lesions. In patients with familial melanoma and/or Dysplastic Nevus Syndrome (DNS) and likewise, in patients who have a clinical history of sporadic melanoma and numerous atypical nevi, melanoma in situ and melanoma in the radial growth phase (RGP) often develop in contiguous association with atypical nevocytic lesions. Currently, the only way to prevent atypical nevi from progressing to melanoma is to persistently monitor and resect them at the earliest signs of changes in shape, size, and/or pigmentation. However, monitoring these lesions by eye or with a handheld, incandescent light source, as done in most clinical settings, is neither an effective nor reliable way for detecting melanoma arising in or adjacent to atypical nevi. In light of the rising incidence of melanoma worldwide, the present limitations concerning early detection of melanoma when juxtaposed to the observation that a patient is often cured by a wide and deep excision of the melanoma when in its early stages, clearly require implementation of new diagnostic devices and techniques that can noninvasively and reproducibly capture melanoma in atypical nevi at first presentation, i.e. prior to excision and histological analysis. Focusing upon optical imaging as a means to address this need, we previously conducted a study, which provided first-time evidence that macroscopic Spectral Imaging has the capacity to detect, in vivo, melanoma arising in melanocytic precursor lesions. Based upon this finding, we now would like to take this project one step further and determine, whether a newly designed acousto-optic tunable filter (AOTF)-based mesoscopic Spectral Imaging device can establish a spectral signature of melanoma developing in or in contiguous association with atypical nevi.