Detection of Melanoma by Mesoscopic Spectral Imaging

通过介观光谱成像检测黑色素瘤

• 批准号: 6644129
• 负责人: DOROTHEA BECKER
• 金额: $ 18.61万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-01 至 2006-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6644129
• 关键词: bioimaging /biomedical imaging; clinical research; diagnosis design /evaluation; early diagnosis; human subject; imaging /visualization /scanning; light emission; melanoma; neoplasm /cancer diagnosis; neoplastic process; nevus; noninvasive diagnosis; patient oriented research; spectrometry

DESCRIPTION: (provided by applicant) In the setting of familial melanoma, comprising about 10 percent overall incidence of melanoma, the presence of atypical nevi is associated with a nearly 100 percent risk of developing primary melanoma by age 70. However, atypical nevi also occur outside the familial melanoma setting, and it is estimated that 40-60 percent of sporadic melanomas develop from these melanocytic precursor lesions. In patients with familial melanoma and/or Dysplastic Nevus Syndrome (DNS) and likewise, in patients who have a clinical history of sporadic melanoma and numerous atypical nevi, melanoma in situ and melanoma in the radial growth phase (RGP) often develop in contiguous association with atypical nevocytic lesions. Currently, the only way to prevent atypical nevi from progressing to melanoma is to persistently monitor and resect them at the earliest signs of changes in shape, size, and/or pigmentation. However, monitoring these lesions by eye or with a handheld, incandescent light source, as done in most clinical settings, is neither an effective nor reliable way for detecting melanoma arising in or adjacent to atypical nevi. In light of the rising incidence of melanoma worldwide, the present limitations concerning early detection of melanoma when juxtaposed to the observation that a patient is often cured by a wide and deep excision of the melanoma when in its early stages, clearly require implementation of new diagnostic devices and techniques that can noninvasively and reproducibly capture melanoma in atypical nevi at first presentation, i.e. prior to excision and histological analysis. Focusing upon optical imaging as a means to address this need, we previously conducted a study, which provided first-time evidence that macroscopic Spectral Imaging has the capacity to detect, in vivo, melanoma arising in melanocytic precursor lesions. Based upon this finding, we now would like to take this project one step further and determine, whether a newly designed acousto-optic tunable filter (AOTF)-based mesoscopic Spectral Imaging device can establish a spectral signature of melanoma developing in or in contiguous association with atypical nevi.

描述：（由申请人提供）在家族性黑色素瘤的情况下， 占黑色素瘤总发病率的10%， 非典型痣与几乎100%的 原发性黑色素瘤然而，非典型痣也发生在 家族性黑色素瘤，据估计，40- 60%的散发性黑色素瘤， 黑色素瘤从这些黑色素细胞前体病变发展而来。患者 家族性黑色素瘤和/或发育不良痣综合征（DNS），同样， 具有散发性黑色素瘤临床病史和大量非典型性黑色素瘤的患者 痣、原位黑色素瘤和放射状生长期黑色素瘤（RGP）通常 发展为与非典型痣细胞病变连续相关。目前， 防止非典型痣发展为黑色素瘤的唯一方法是 在最早的形状变化迹象中持续监测和切除它们， 大小和/或色素沉着。然而，通过眼睛或使用 如在大多数临床环境中所做的那样， 用于检测黑素瘤的有效或可靠的方法， 与非典型痣相邻鉴于黑色素瘤发病率的上升 在世界范围内，目前关于黑色素瘤早期检测的局限性， 与观察到的病人往往是治愈广泛和深刻的 切除黑色素瘤时，在其早期阶段，显然需要 新的诊断设备和技术的实施， 并且在第一次出现时可重复地捕获非典型痣中的黑素瘤，即， 在切除和组织学分析之前。 专注于光学成像作为解决这一需求的手段，我们以前 进行了一项研究，首次提供了宏观光谱的证据， 成像具有在体内检测黑色素细胞中产生的黑色素瘤的能力， 前驱病变基于这一发现，我们现在想把这个 更进一步地预测并确定，新设计的声光 基于可调谐滤波器（AOTF）的介观光谱成像装置可以建立一个 发生于或与之相邻的黑色素瘤的光谱特征 非典型痣