Neurochem Chip: Study of Neurotransmitter Release
Neurochem 芯片:神经递质释放的研究
基本信息
- 批准号:6523652
- 负责人:
- 金额:$ 14.26万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2001
- 资助国家:美国
- 起止时间:2001-09-30 至 2004-08-31
- 项目状态:已结题
- 来源:
- 关键词:bioengineering /biomedical engineering biosensor device ceramics corpus striatum electronic recording system frontal lobe /cortex gamma aminobutyrate glutamates hippocampus laboratory rat microelectrodes microprocessor /microchip miniature biomedical equipment neurochemistry neurotransmitter transport telemetry
项目摘要
DESCRIPTION: (provided by the applicant)
The capability to record neurotransmitter release in totally unrestrained
animals to study the effects of drugs of abuse in prenatal animals, rat
adolescent models of drug abuse and transgenic mice, has been limited, or even
unattainable. We propose to develop a technology we call Neurochem Chip. This
technology involves the development of microsensors that are capable of nearly
specifically measuring neurochemicals such as glutamate and GABA, using
photolithographically designed microelectrodes and a self-referencing recording
approach. In this Stage 1 proposal, Neurochem Chips will be integrated to
polyimide flex cables in order to
carry out recordings of neurotransmitter release in the frontal cortex,
striatum and hippocampus in tethered, awake behaving rats. Pilot studies and
prior work support that Neurochem Chip can reliably measure L-glutamate using a
self-referencing recording paradigm. However, refinements in technology are
needed in order to carry out such recordings in the awake behaving animal to
lay the foundation for the development of a totally untethered recording system
involving telemetry technology. In addition, a new prototype sensor that will
allow for the simultaneous measures of both glutamate and GABA will be
investigated. In Stage 2, the recording circuitry will be miniaturized and a
total telemetric system will be developed so that large numbers of rats and
mice can be recorded. In general, these technologies will allow for the rapid
screening of the effects of drugs of abuse on brain neurotransmitter systems,
acutely and chronically, in both adult and developing rats and mice which
cannot be carried out using current technology. In addition, Neurochem Chip can
possibly be developed to measure a large number of other neurotransmitters.
描述:(申请人提供)
记录神经递质释放的能力完全不受限制
研究药物滥用对产前动物的影响,
药物滥用和转基因小鼠的青少年模型,一直是有限的,甚至
高不可攀我们建议开发一种叫做神经化学芯片的技术。这
这项技术涉及到微型传感器的开发,
专门测量神经化学物质,如谷氨酸和GABA,使用
电子照相设计的微电极和自参考记录
approach.在第一阶段的提案中,神经化学芯片将被集成到
聚酰亚胺柔性电缆,
记录额叶皮层神经递质的释放,
纹状体和海马区。试点研究和
先前的工作支持Neurochem Chip可以使用
自我参照记录范式然而,技术的改进是
为了在清醒的行为动物中进行这种记录,
为研制完全不系留的记录系统奠定了基础
涉及遥测技术。此外,一个新的原型传感器,将
允许同时测量谷氨酸和GABA,
研究了在第二阶段,记录电路将小型化,
将开发一个总的遥测系统,以便大量的老鼠和
老鼠可以记录。总的来说,这些技术将允许快速
筛查滥用药物对大脑神经递质系统的影响,
急性和慢性,在成年和发育中的大鼠和小鼠,
无法使用现有技术进行。此外,神经化学芯片还可以
可能被开发来测量大量的其他神经递质。
项目成果
期刊论文数量(2)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Greg A. Gerhardt其他文献
Chronic Intracerebral Delivery of Trophic Factors via a Programmable Pump as a Treatment for Parkinsonism.
通过可编程泵慢性脑内输送营养因子作为帕金森病的治疗方法。
- DOI:
- 发表时间:
2001 - 期刊:
- 影响因子:0
- 作者:
R. Grondin;Zhiming Zhang;D. Elsberry;Greg A. Gerhardt;Don M. Gash - 通讯作者:
Don M. Gash
Adderall® produces increased striatal dopamine release and a prolonged time course compared to amphetamine isomers
- DOI:
10.1007/s00213-006-0550-9 - 发表时间:
2006-10-10 - 期刊:
- 影响因子:3.300
- 作者:
B. Matthew Joyce;Paul E. A. Glaser;Greg A. Gerhardt - 通讯作者:
Greg A. Gerhardt
Multisite microelectrode arrays for measurements of multiple neurochemicals
用于测量多种神经化学物质的多位点微电极阵列
- DOI:
10.1109/iembs.2004.1404493 - 发表时间:
2004 - 期刊:
- 影响因子:0
- 作者:
J. Burmeister;T. D. Coates;Greg A. Gerhardt - 通讯作者:
Greg A. Gerhardt
Costs of Implementing Quality in Research Practice.
在研究实践中实施质量的成本。
- DOI:
- 发表时间:
2019 - 期刊:
- 影响因子:0
- 作者:
O. Meagan Littrell;Claudia Stoeger;H. Maier;H. Fuchs;M. Hrabě de Angelis;L. Cassis;Greg A. Gerhardt;Richard Grondin;V. Gailus - 通讯作者:
V. Gailus
Reply: GDNF poses troubling questions for doctors, drug maker.
答复:GDNF 给医生、制药商带来了令人不安的问题。
- DOI:
10.1002/ana.20880 - 发表时间:
2006 - 期刊:
- 影响因子:11.2
- 作者:
J. Slevin;Greg A. Gerhardt;Charles D. Smith;D. Gash;A. Young - 通讯作者:
A. Young
Greg A. Gerhardt的其他文献
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{{ truncateString('Greg A. Gerhardt', 18)}}的其他基金
Tonic and Phasic Glutamate Release from Psychomotor Stimulants
精神运动兴奋剂的强效和阶段性谷氨酸释放
- 批准号:
8446339 - 财政年份:2012
- 资助金额:
$ 14.26万 - 项目类别:
Tonic and Phasic Glutamate Release from Psychomotor Stimulants
精神运动兴奋剂的强效和阶段性谷氨酸释放
- 批准号:
8322257 - 财政年份:2012
- 资助金额:
$ 14.26万 - 项目类别:
NEUROCHEMICAL STUDIES OF THE AGING BASAL GANGLIA
老化基底神经节的神经化学研究
- 批准号:
7371007 - 财政年份:2007
- 资助金额:
$ 14.26万 - 项目类别:
Neurochem Chip: Methodology to Study Untethered Rats
Neurochem 芯片:研究不受束缚的大鼠的方法
- 批准号:
7252437 - 财政年份:2003
- 资助金额:
$ 14.26万 - 项目类别:
Neurochem Chip: Methodology to Study Untethered Rats
Neurochem 芯片:研究不受束缚的大鼠的方法
- 批准号:
6704868 - 财政年份:2003
- 资助金额:
$ 14.26万 - 项目类别:
Neurochem Chip: Methodology to Study Untethered Rats
Neurochem 芯片:研究不受束缚的大鼠的方法
- 批准号:
6807017 - 财政年份:2003
- 资助金额:
$ 14.26万 - 项目类别:
Neurochem Chip: Methodology to Study Untethered Rats
Neurochem 芯片:研究不受束缚的大鼠的方法
- 批准号:
7084604 - 财政年份:2003
- 资助金额:
$ 14.26万 - 项目类别:
Neurochem Chip: Methodology to Study Untethered Rats
Neurochem 芯片:研究不受束缚的大鼠的方法
- 批准号:
6920043 - 财政年份:2003
- 资助金额:
$ 14.26万 - 项目类别:
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