CELLULAR AND MOLECULAR RESPONSES IN LUNG DISEASE

这一计划的主要目标是培养年轻的内科科学家，使其成为肺部研究的全职学术生涯。重点将放在培养和培养高素质的受训人员上，使他们能够获得成长为独立调查人员所需的必要知识和技能。这项研究将在犹他大学医学系、儿科系、生物学系、生物化学系、病理学系或人类遗传系的积极高级研究员的亲自指导下进行。该培训计划利用了遗传学和分子生物学大学的现有优势，同时以患者为导向的研究与正在进行的急性肺损伤，特别是急性呼吸窘迫综合征(ARDS)的研究保持一致。我们的研究培训理念是，这样的培训最好是通过受训者和教员之间最直接的日常互动来实现，这些教官已经证明成功地为个人的研究生涯做好了准备。由于不同的导师之间已经建立了密切的协作关系以及不断发展的协会和协作，因此存在着一个非常有利于采取多学科方法的环境。指导研究培训将辅以正式的课程工作、讲座、会议、研讨会和其他相关的教育形式，以便学员在培训结束时为制定创新和有价值的肺部疾病研究计划做好准备。拟议的专家代表了一群活跃的科学家，他们从事与肺部健康和疾病相关的五个相互关联的主题领域的研究。每个教官都有一个由NIH资助的生产性研究计划。主题领域包括：1)白细胞生物学；2)血管细胞生物学；3)发育生物学与衰老；4)人类遗传病；5)以病人为中心的研究。我们相信，该项目将使学员能够掌握现代生物医学研究的复杂性，并将提供对医学问题研究所需的跨学科协作方法的欣赏。

The primary goal of this proposed program is to train young physician- scientists for a full-time academic career in pulmonary research. The emphasis will be placed on developing and cultivating highly qualified trainees, allowing them to acquire the necessary knowledge and skills required to evolve as independent investigators. The research will be conducted under the personal preceptorship of active senior investigators in the departments of Medicine, Pediatrics, Biology, Biochemistry, Pathology or Human Genetics at the University of Utah. The training program utilizes established strengths at the University of genetics and molecular biology while the patient-oriented research is aligned with ongoing investigations in acute lung injury, in particular the Acute Respiratory Distress Syndrome (ARDS). Our research training philosophy is that such training can best be achieved on the basis of the most direct day-to-day interaction between trainees and faculty preceptors who have demonstrated success in preparing individuals for careers in research. A highly conducive environment for a multi- disciplinary approach exists due to the close collaborative ties already developed among various preceptors and evolving associations and collaborations. The preceptorial research training will be supplemented with formal course work, lectures, conferences, seminars, and other pertinent educational modalities in order to prepare the trainees to formulate innovative and meritorious research programs in pulmonary diseases at the conclusion of their training. The proposed preceptors represent a group of active scientists engaged in research in five interrelated thematic areas relevant to lung health and disease. Each preceptor has an NIH-funded productive research program. The thematic areas include: 1) Leukocyte Biology; 2) Vascular Cell Biology; 3) Developmental Biology and Aging; 4) Human Genetic Diseases; and 5) Patient-Oriented Research. We believe the program will enable the trainees to master the complexities of modern biomedical research, and will provide an appreciation for the collaborative interdisciplinary approach required for research into medical problems.