Mechanically Chiral Rotaxanes in Catalysis, Sensing and Materials

轮烷是典型的互锁分子，其中线性组分被捕获在环状分子内，就像线上的珠子，而索烃是由两个环相互穿过形成的分子，就像链中的链接。像这样将分子组分保持在一起会大大改变它们的性质，并导致新的功能和应用。事实上，自然界已经利用这种方法来稳定链烷结构中的DNA（Nature 1967）和轮烷形式的肽（Acc.Chem.Res.2015）。对于机械互锁分子的性质的介绍，参见：“Chemical consequences of mechanical bonding in catenanes and rotaxanes”（Chem.Commun. 2014年）。在这个项目中，我们将使用尖端技术开发的戈尔达集团（J。Soc. 2018）合成轮烷和索烃基于Tavassoli Group开发的人工生物活性分子（Nature Chemistry 2017），并展示其作为化学生物学新工具的应用。

Rotaxanes, in which a linear component is trapped within a ring-shaped molecule like a bead on a thread, and catenanes, molecules formed of two rings threaded through one another like links in a chain, are the archetypal interlocked molecules. Holding the molecular components together like this changes their properties considerably and leads to new functions and applications. Indeed, nature has taken advantage of this approach to stabilise DNA in catenane structures (Nature 1967) and peptides as rotaxanes (Acc. Chem. Res. 2015). For an introduction to the properties of mechanically interlocked molecules see: "Chemical consequences of mechanical bonding in catenanes and rotaxanes" (Chem. Commun. 2014). In this project we will use cutting edge techniques developed in the Goldup Group (J. Am. Chem. Soc. 2018) to synthesise rotaxanes and catenanes based on artificial biologically active molecules developed by the Tavassoli Group (Nature Chemistry 2017) and demonstrate their application as new tools for chemical biology.