Characterising neural activation and functional connectivity differences between resilient and non-resilient young people

尽管暴露在极端的逆境或创伤中，许多人仍然能够保持积极的心理健康，并成功地适应这些情况。研究人员强调了理解韧性的重要性，以提高我们对精神疾病和精神病理学的理解。大脑在韧性方面的作用需要特别关注，因为它在调节对外部事件的行为反应方面发挥着关键作用。FMRI研究探讨了复原力的潜在机制，建立了复原组和非复原组之间的神经激活和功能连接差异。然而，准确地定义弹性会带来困难，因为以前应用于检测和测量这一结构的标准和界限是武断的。量化创伤暴露的复杂性，如时间、持续时间和严重程度，在很大程度上被忽视了。该项目旨在提高我们对弹性的理解，并确定与无弹性的同龄人相比，有弹性的年轻人在神经激活和功能连通性方面的差异。利用包含有关创伤和生活事件的详细信息的现有数据集，该项目旨在利用一个大型的多级数据集来完善恢复力的结构，在同一数据集中确定与恢复力相关的神经激活和功能连接的模式，并在包含类似信息的独立数据集中复制恢复力的结构和相关发现。

Despite exposure to extreme adversity or trauma, many individuals are able to maintain positive mental health and successfully adapt to cope in these situations. Researchers have highlighted the importance of understanding resilience to improve our understanding of mental illness and psychopathology. The brain's role in resilience requires particular attention as it is plays a critical role in moderating behavioural responses to external events. fMRI studies have examined the underlying mechanisms of resilience, establishing neural activation and functional connectivity differences between resilient and non-resilient groups. However, defining resilience accurately poses difficulties due to the arbitrary criteria and cut-offs previously applied to detect and measure this construct. The complexities of quantifying exposure to trauma such as timing, duration and severity, have largely been ignored.This project aims to improve our understanding of resilience and identify differences in neural activation and functional connectivity in resilient young people compared to their non-resilient peers. Using existing datasets that contain detailed information about trauma and life events, the project aims to refine the construct of resilience using a large multi-level dataset, identify patterns of neural activation and functional connectivity related to resilience in the same dataset and replicate the resilience constructs and associated findings in independent datasets which contain similar information.