Characterising neural activation and functional connectivity differences between resilient and non-resilient young people

表征有弹性和无弹性年轻人之间的神经激活和功能连接差异

• 批准号: 2102307
• 金额: --
• 依托单位: University of Bath
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2018
• 资助国家: 英国
• 起止时间: 2018 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2102307
• 关键词: Characterising; neural; activation; functional; connectivity

Despite exposure to extreme adversity or trauma, many individuals are able to maintain positive mental health and successfully adapt to cope in these situations. Researchers have highlighted the importance of understanding resilience to improve our understanding of mental illness and psychopathology. The brain's role in resilience requires particular attention as it is plays a critical role in moderating behavioural responses to external events. fMRI studies have examined the underlying mechanisms of resilience, establishing neural activation and functional connectivity differences between resilient and non-resilient groups. However, defining resilience accurately poses difficulties due to the arbitrary criteria and cut-offs previously applied to detect and measure this construct. The complexities of quantifying exposure to trauma such as timing, duration and severity, have largely been ignored.This project aims to improve our understanding of resilience and identify differences in neural activation and functional connectivity in resilient young people compared to their non-resilient peers. Using existing datasets that contain detailed information about trauma and life events, the project aims to refine the construct of resilience using a large multi-level dataset, identify patterns of neural activation and functional connectivity related to resilience in the same dataset and replicate the resilience constructs and associated findings in independent datasets which contain similar information.

尽管面临极端逆境或创伤，许多人能够保持积极的心理健康，并成功地适应这些情况。研究人员强调了理解韧性的重要性，以提高我们对精神疾病和精神病理学的理解。大脑在恢复力中的作用需要特别关注，因为它在调节对外部事件的行为反应方面起着关键作用。功能磁共振成像研究已经研究了弹性的潜在机制，建立了弹性和非弹性群体之间的神经激活和功能连接差异。然而，准确地定义弹性造成的困难，由于任意的标准和截止以前应用于检测和测量这一结构。量化创伤暴露的复杂性，如时间，持续时间和严重程度，在很大程度上被忽视了。本项目旨在提高我们对弹性的理解，并确定弹性年轻人与非弹性同龄人相比，神经激活和功能连接的差异。该项目利用包含创伤和生活事件详细信息的现有数据集，旨在使用大型多层次数据集完善弹性结构，确定同一数据集中与弹性相关的神经激活和功能连接模式，并在包含类似信息的独立数据集中复制弹性结构和相关发现。