Laser-Engineered Net Shape Ti/HA Composite Implants

激光设计的净形状 Ti/HA 复合植入物

• 批准号: 6443481
• 负责人: Harold Alexander
• 金额: $ 10万
• 依托单位: BIOLOK INTERNATIONAL, INC.-ORTHOGEN CORP
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-30 至 2004-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6443481
• 关键词: bioengineering /biomedical engineering; biomaterial compatibility; biomaterial development /preparation; bone regeneration; dogs; endosseous dental implant; hydroxyapatites; lasers; medical implant science; technology /technique development; titanium

DESCRIPTION: Endosseous Dental implants are in common use today throughout the world to treat single tooth loss and well as to support dentures. Tissue response to a Dental implant correlates with the composition, surface chemistry, and surface microgeometry of the implant material. The bioactivity of titanium alloy is to be improved through the addition of hydroxyapatite (HA) powder utilizing Laser Engineered Net Shaping (LENS) technology. CP titanium and 6Al-4V-Ti alloy have good biocompatibility but low bioactivity resulting in variable bone response to the implant surface. It is believed that a calcium rich surface potentiates platelet activation and improves fibrin binding to the implant surface. Surface modification through laser microgrooving and chemistry modification through LENS should result is more rapid bone growth and apposition up to the implant surface. The LENS process offers the opportunity to manufacture a unique HA impregnated Ti alloy Dental implant with a cost and ease similar to current manufacturing modalities incorporating optimum surface microgeometry, mechanical design, base material composition and surface chemistry. Such an implant could be implanted and loaded at the time of tooth extraction providing the patient with a cost effective new tooth after just one or two sittings, instead of the usual 3 to 6 months.

描述：骨内牙科植入物在今天的普遍使用， 世界上最大的治疗单牙缺失和支持假牙的公司。组织 对牙科植入物的反应与组合物、表面 化学和植入物材料的表面微观几何形状。生物活性 通过添加羟基磷灰石（HA）来改善钛合金的力学性能 粉末采用激光工程净成形（透镜）技术。CP钛 6Al-4V-Ti合金具有良好的生物相容性，但生物活性较低， 骨对种植体表面的反应不同。据信， 丰富的表面增强血小板活化，并提高纤维蛋白结合到 植入物表面。通过激光微槽和化学进行表面改性 通过透镜进行的修饰应该会导致骨生长更快， 附着到植入物表面。透镜过程提供了机会 制造独特的HA浸渍的钛合金牙科植入物， 与现有制造模式相似， 微观几何形状、机械设计、基材成分和表面 化学.这样的植入物可以在牙齿植入时植入和加载。 拔牙为患者提供了一个成本有效的新牙后，只有一个 或两次开庭，而不是通常的3至6个月。