Crystalline Inorganic Anion Exchanger 188Re Generator

描述(申请人提供)：放射免疫疗法(RIT)使用抗体将寿命相对较短的同位素输送到肿瘤附近，因此衰变时发出的辐射(最好是贝塔粒子或阿尔法粒子)具有非常高的摧毁肿瘤细胞的可能性。这是一种治疗多种癌症的有效方法。扩大RIT使用的一个关键是获得更多与其他抗体相容的同位素。该项目开发了一种按需提供188Re(测试型发射器)的发电机。188Re的半衰期很短(16.9h)，这使得向目标发射大剂量辐射成为可能，而对其他组织的伤害最小。188Re是188W的衰变产物，以无机阴离子交换剂上的钨酸盐形式存在于发生器中。无机离子交换器比有机离子交换器更耐辐射，并且可以针对所需的离子进行定制。本项目中的阴离子交换剂是合成水滑石，如Mg2Al(OH)7，以及其他结构相关的化合物，是有效的阴离子交换剂，如LiAl2(OH)7。它们具有这一应用所必需的性质(对WO4=的高亲和力，对ReO4的低亲和力)。这些性能将通过可控地改变化合物的组成和结晶度来优化。

DESCRIPTION (provided by applicant): Radioimmunotherapy (RIT) uses an antibody to deliver a relatively short lived isotope into close proximity with a tumor so the radiation emitted on decay (preferably a beta or alpha particle) has a very high probability of destroying cells in the tumor. It is an effective treatment for a variety of cancers. One key to expanding the use of RIT is the availability of additional isotopes that are compatible with other antibodies. This project develops a generator to deliver188Re (a beta emitter) on demand. The short half-life (16.9 h) of 188Re makes it possible to deliver large doses of radiation to the target with minimal harm to other tissues. 188Re is the decay product of 188W, present in the generator as tungstate on an inorganic anion exchanger. Inorganic ion exchangers are more radiation resistant than organic ones, and can be tailored to be specific for the desired ion. The anion exchangers in this project are synthetic hydrotalcites, such as Mg2AI(OH)7, and other structurally related compounds which are effective anion exchangers, such as LiAI2(OH)7. They have the necessary properties (high affinity for WO4= and low affinity for ReO4) for this application. These properties will be optimized by controllably varying the composition and crystallinity of the compounds.