Crystalline Inorganic Anion Exchanger 188Re Generator

描述（由申请人提供）：放射免疫疗法（RIT）使用抗体将相对短寿命的同位素递送到肿瘤附近，因此衰变时发射的辐射（优选β或α粒子）具有非常高的破坏肿瘤细胞的可能性。它是治疗多种癌症的有效方法。扩大RIT使用的一个关键是与其他抗体相容的其他同位素的可用性。本项目开发了一个发生器，以提供188 Re（β发射器）的需求。188 Re的半衰期较短（16.9小时），因此可以将大剂量的辐射传递到目标，而对其他组织的伤害最小。188 Re是188 W的衰变产物，在发生器中以钨酸盐的形式存在于无机阴离子交换剂上。无机离子交换剂比有机离子交换剂更耐辐射，并且可以针对所需离子进行定制。该项目中的阴离子交换剂是合成的水滑石，如Mg2Al（OH）7，以及作为有效阴离子交换剂的其他结构相关的化合物，如LiAl 2（OH）7。它们具有该应用所需的性质（对WO4=的高亲和力和对ReO4的低亲和力）。这些性能将通过可控地改变化合物的组成和结晶度来优化。

DESCRIPTION (provided by applicant): Radioimmunotherapy (RIT) uses an antibody to deliver a relatively short lived isotope into close proximity with a tumor so the radiation emitted on decay (preferably a beta or alpha particle) has a very high probability of destroying cells in the tumor. It is an effective treatment for a variety of cancers. One key to expanding the use of RIT is the availability of additional isotopes that are compatible with other antibodies. This project develops a generator to deliver188Re (a beta emitter) on demand. The short half-life (16.9 h) of 188Re makes it possible to deliver large doses of radiation to the target with minimal harm to other tissues. 188Re is the decay product of 188W, present in the generator as tungstate on an inorganic anion exchanger. Inorganic ion exchangers are more radiation resistant than organic ones, and can be tailored to be specific for the desired ion. The anion exchangers in this project are synthetic hydrotalcites, such as Mg2AI(OH)7, and other structurally related compounds which are effective anion exchangers, such as LiAI2(OH)7. They have the necessary properties (high affinity for WO4= and low affinity for ReO4) for this application. These properties will be optimized by controllably varying the composition and crystallinity of the compounds.