Crystalline Inorganic Anion Exchanger 188Re Generator

结晶无机阴离子交换器188Re发生器

• 批准号: 6550283
• 负责人: ALAN J CISAR
• 金额: $ 11.21万
• 依托单位: LYNNTECH, INC.
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-08-16 至 2003-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6550283
• 关键词: anions; beta radiation; bioengineering /biomedical engineering; biomedical equipment development; energy source; heavy metals; tungsten

DESCRIPTION (provided by applicant): Radioimmunotherapy (RIT) uses an antibody to deliver a relatively short lived isotope into close proximity with a tumor so the radiation emitted on decay (preferably a beta or alpha particle) has a very high probability of destroying cells in the tumor. It is an effective treatment for a variety of cancers. One key to expanding the use of RIT is the availability of additional isotopes that are compatible with other antibodies. This project develops a generator to deliver188Re (a beta emitter) on demand. The short half-life (16.9 h) of 188Re makes it possible to deliver large doses of radiation to the target with minimal harm to other tissues. 188Re is the decay product of 188W, present in the generator as tungstate on an inorganic anion exchanger. Inorganic ion exchangers are more radiation resistant than organic ones, and can be tailored to be specific for the desired ion. The anion exchangers in this project are synthetic hydrotalcites, such as Mg2AI(OH)7, and other structurally related compounds which are effective anion exchangers, such as LiAI2(OH)7. They have the necessary properties (high affinity for WO4= and low affinity for ReO4) for this application. These properties will be optimized by controllably varying the composition and crystallinity of the compounds.

描述（由申请人提供）：放射免疫疗法（RIT）使用抗体将相对较短的同位素传递到肿瘤附近，因此衰变时发射的辐射（最好是β或α粒子）具有非常高的破坏肿瘤细胞的可能性。它是治疗多种癌症的有效方法。扩大RIT使用的一个关键是与其他抗体兼容的额外同位素的可用性。该项目开发了一种发电机，可按需提供188re （β发射极）。188Re的半衰期很短（16.9小时），这使得它可以在对其他组织造成最小伤害的情况下向目标发射大剂量的辐射。188Re是188W的衰变产物，在发生器中以钨酸盐的形式存在于无机阴离子交换器上。无机离子交换器比有机离子交换器更耐辐射，并且可以针对所需的离子进行定制。本项目的阴离子交换剂为人工合成的水滑石，如Mg2AI(OH)7，以及其他结构相关的有效阴离子交换剂，如LiAI2(OH)7。对于这个应用程序，它们具有必要的特性（对WO4的高亲和性和对ReO4的低亲和性）。通过可控地改变化合物的组成和结晶度，这些性能将得到优化。