Crystalline Inorganic Anion Exchanger 188Re Generator

结晶无机阴离子交换器188Re发生器

• 批准号: 6550283
• 负责人: ALAN J CISAR
• 金额: $ 11.21万
• 依托单位: LYNNTECH, INC.
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-08-16 至 2003-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6550283
• 关键词: anions; beta radiation; bioengineering /biomedical engineering; biomedical equipment development; energy source; heavy metals; tungsten

DESCRIPTION (provided by applicant): Radioimmunotherapy (RIT) uses an antibody to deliver a relatively short lived isotope into close proximity with a tumor so the radiation emitted on decay (preferably a beta or alpha particle) has a very high probability of destroying cells in the tumor. It is an effective treatment for a variety of cancers. One key to expanding the use of RIT is the availability of additional isotopes that are compatible with other antibodies. This project develops a generator to deliver188Re (a beta emitter) on demand. The short half-life (16.9 h) of 188Re makes it possible to deliver large doses of radiation to the target with minimal harm to other tissues. 188Re is the decay product of 188W, present in the generator as tungstate on an inorganic anion exchanger. Inorganic ion exchangers are more radiation resistant than organic ones, and can be tailored to be specific for the desired ion. The anion exchangers in this project are synthetic hydrotalcites, such as Mg2AI(OH)7, and other structurally related compounds which are effective anion exchangers, such as LiAI2(OH)7. They have the necessary properties (high affinity for WO4= and low affinity for ReO4) for this application. These properties will be optimized by controllably varying the composition and crystallinity of the compounds.

描述（由申请人提供）：放射免疫疗法（RIT）使用抗体将寿命相对较短的同位素传递到肿瘤附近，因此衰变时发出的辐射（最好是β或α粒子）很有可能破坏肿瘤中的细胞。它是治疗多种癌症的有效方法。扩大 RIT 用途的关键之一是获得与其他抗体相容的其他同位素。该项目开发了一种发电机，可按需提供 188Re（β 发射体）。 188Re 的半衰期短（16.9 小时），使其能够向目标提供大剂量的辐射，同时对其他组织的伤害最小。 188Re 是 188W 的衰变产物，以钨酸盐形式存在于发生器中的无机阴离子交换剂上。无机离子交换剂比有机离子交换剂更耐辐射，并且可以针对所需离子进行定制。该项目中的阴离子交换剂是合成水滑石，例如Mg2Al(OH)7，以及其他结构相关的有效阴离子交换剂化合物，例如LiAl2(OH)7。它们具有该应用所需的特性（对 WO4= 的高亲和力和对 ReO4 的低亲和力）。这些特性将通过可控地改变化合物的组成和结晶度来优化。