Inorganic Ion Exchange Materials for 90Sr/90Y Generator

90Sr/90Y发生器用无机离子交换材料

• 批准号: 6444984
• 负责人: ALAN J CISAR
• 金额: $ 41.06万
• 依托单位: LYNNTECH, INC.
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-07-15 至 2004-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6444984
• 关键词: biomedical equipment development; chemical synthesis; neoplasm /cancer radioimmunotherapy; radiochemistry; radiopharmacology; radiotracer; strontium; technology /technique development; yttrium

DESCRIPTION (provided by applicant): Because it is an energetic pure beta emitter with a half-life on the scale of days (64.1 hr) 90Y is seeing increasing interest as an isotope for use as a radiation source for radioimmunotherapy (RIT). Current processes for obtaining 90Y involve extracting and purifying the 90Y produced by the decay of 90Sr in solution using a liquid-liquid extraction process. The isotope is produced at a centralized location and shipped to users worldwide. The generator proposed here will permit the production of the desired isotope locally in a hospital or regional radiopharmacy where it can be used immediately. Phase I identified two inorganic ion exchange materials that can be loaded with a "cow" of 90Sr and "milked" to produce a carrier-free solution of 90Y ready for immediate use. In Phase II this technology will be further refined and used in the design of a generator capable of delivering a useful quantity of 90Y on a weekly basis in a chemical form suitable for radiopharmaceutical applications. The generator will be fabricated and its efficacy will be demonstrated. The superior long-term stability of the inorganic ion exchanger compared to organic ion exchange materials will be demonstrated. PROPOSED COMMERCIAL APPLICATION: Radioimmunotherapy, where an antibody selectively delivers a radiation source directly to a tumor, is seeing increasing interest as a means of attacking tumors by delivering a therapeutic dose of radiation to the tumor with minimal exposure for other organs. Currently 90Y is produced by a complex multistep process process and supplied from a central source, with clinicians dependent on reliable delivery to have the isotope they need when they need it. The generator proposed here would make 90Y as readily available as 99m Tc is now and greatly increase the use of this valuable therapy. As an alternative, the developed technology could be utilized on a larger scale to simplify the current 90Y production method.

描述（由申请人提供）：因为它是一个充满活力的纯β 90 Y的半衰期为天（64.1小时）的发射体 作为放射源使用的同位素的兴趣日益增加， 放射免疫疗法（RIT）。目前获得90 Y的方法包括 提取纯化溶液中90 Sr衰变产生的90 Y， 使用液-液萃取工艺。这种同位素是在 集中定位并运送给全球用户。 这里提出的发生器将允许生产所需的同位素 在医院或区域放射性药物治疗所， 立即第一阶段确定了两种无机离子交换材料， 装载90 Sr的“奶牛”并“挤奶”以产生无载体溶液 90后准备立即使用。在第二阶段，这项技术将进一步 改进并用于发电机的设计，能够提供有用的 每周以化学形式给予90 Y， 放射性药物应用。发电机将被制造， 功效将得到证明。优越的上级长期稳定性， 无机离子交换剂与有机离子交换材料相比， 演示。 拟定商业应用：放射免疫疗法，其中抗体选择性地将辐射源直接递送到肿瘤，通过将治疗剂量的辐射递送到肿瘤而对其他器官的暴露最小化，作为攻击肿瘤的手段，越来越受到关注。 目前，90 Y是由一个复杂的多步骤的过程中产生的，并从一个中央来源提供，与临床医生依赖于可靠的交付，他们需要的同位素时，他们需要它。这里提出的发生器将使90 Y作为容易获得的99 m Tc是现在和大大增加使用这种有价值的治疗。 作为替代方案，开发的技术可以在更大规模上使用，以简化目前的90 Y生产方法。