Novel Pyrogen Removal System

新型热原去除系统

• 批准号: 6655996
• 负责人: Stuart Nemser
• 金额: $ 4.42万
• 依托单位: COMPACT MEMBRANE SYSTEMS, INC.
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-06-01 至 2004-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6655996
• 关键词: biomedical equipment; endotoxins; gram negative bacteria; hemodialysis; molecular film; nosocomial infection control; oxidizing agents; polymers; pyrogens; technology /technique development; titanium; ultrafiltration; water flow; water quality; water treatment

DECRIPTION (Provided by applicant): Pyrogen-free water (PFW) is required in many applications. Laboratories use it as solvent for compound preparation, culture media, and equipment rinse. Hospitals use it for cleaning to prepare solutions for injections, lV's, and hemodialysis. Pharmaceutical manufacturers use it to formulate injectable drug preparations. Pyrogens, or fever-inducers, are derived from metabolic byproducts of bacteria, molds, yeasts, viruses, and certain chemicals. Current technology used to prepare PFW include distillation, reverse osmosis, and ultrafiltration. Overall these processes are complicated, prone to failure, and in many cases do not remove sufficient pyrogens and are not ideal for small scale facilities. In this program, Compact Membrane Systems (CMS) has identified a simple (push one button) system that is easily integrated into existing systems for pyrogen removal. The basis of the CMS technology is a novel oxidizing system that both kills microorganisms and oxidizes their endotoxins. In Phase I we will develop this novel oxidizing system and demonstrate superior pyrogen removal compared to existing technologies. PROPOSED COMMERCIAL APPLICATION: Water for Injection including Kidney Dialysis water and pharmaceutical water.

说明（由申请人提供）： 需要无热原水 (PFW) 许多应用程序。实验室用它作为化合物制备的溶剂， 培养基和设备冲洗。医院用它进行清洁准备 用于注射、静脉注射和血液透析的溶液。药品生产企业 用它来配制注射药物制剂。热原，或发烧诱导物， 源自细菌、霉菌、酵母、病毒的代谢副产物， 某些化学品。 目前用于制备 PFW 的技术包括蒸馏、反渗透、 和超滤。总的来说，这些过程很复杂，容易失败， 并且在许多情况下不能去除足够的热原，并且对于小型设备来说并不理想 规模设施。在此计划中，紧凑型膜系统 (CMS) 具有 确定了一个简单（按一个按钮）的系统，可以轻松集成到 现有的热原去除系统。 CMS 技术的基础是一种新颖的氧化系统，该系统既能杀死 微生物并氧化其内毒素。在第一阶段我们将开发这个 新颖的氧化系统，与相比具有优越的热原去除能力 现有技术。 拟议的商业应用： 注射用水包括肾透析用水和制药用水。