Laser Assisted Cartilage Repair Using Collagen Adhesives

使用胶原蛋白粘合剂进行激光辅助软骨修复

• 批准号: 6486277
• 负责人: BARBARA Ann SOLTZ
• 金额: $ 9.84万
• 依托单位: CONVERSION ENERGY ENTERPRISES
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-04-17 至 2002-10-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6486277
• 关键词: articular cartilage; biomaterial development /preparation; biomedical equipment development; collagen; histology; laser therapy; limb injury; miniature swine; orthopedics; surgery material /equipment

Articular cartilage damage affects millions of people. This condition is exacerbated by an ageing but increasingly more active population. The two portentous independent variables associated with inferior treatment of articular cartilage lesions are healing response and cartilage regeneration. Laser-assisted welding using a derivatized collagen solder may aid in the prevention of progressive degenerative joint disease and may augment or ultimately replace total joint arthroplasty. We have assembled a multi-disciplinary team to investigate the efficacy of laser activated collagen formulations as an adhesive and as an acellular graft that permits and/or promotes cell invasion. Laser operating parameters will be optimized to promote strong solder crosslinks to cartilage. An integrated temperature controller will be used to prevent peripheral tissue damage. A laser handpiece will be modified for use in the animal studies. Custom designed equipment will be used to accurately measure previously unknown values for inherent solder strength, strength of the repair and type of failure mode. Histology will assess the potential to promote cell invasion and synthesis of new extracellular matrix. It is anticipated that the Phase I results will lay the foundation for further animal studies and clinical trials in subsequent Phase II and Phase III projects. PROPOSED COMMERCIAL APPLICATIONS: The development of laser procedures to repair full thickness articular defects will benefit the millions of people who are suffering from osteoarthritis. This technology may provide orthopaedic surgeons with new techniques which can reduce operating time, convalescence and hospital stays.

关节软骨损伤影响数百万人。这种情况因人口老龄化但日益活跃而加剧。与关节软骨损伤治疗效果差相关的两个重要自变量是愈合反应和软骨再生。使用衍生胶原焊料的激光辅助焊接可能有助于预防进行性退行性关节疾病，并可能增强或最终取代全关节置换术。我们已经组建了一个多学科团队来研究激光活化胶原蛋白制剂作为粘合剂和作为允许和/或促进细胞侵袭的脱细胞移植物的功效。将优化激光操作参数，以促进强焊料与软骨的交联。集成温度控制器将用于防止外周组织损伤。将修改激光手柄以用于动物研究。定制设计的设备将用于精确测量先前未知的固有焊接强度、修复强度和失效模式类型的值。组织学将评估促进细胞侵袭和合成新的细胞外基质的潜力。预计I期研究结果将为后续II期和III期项目的进一步动物研究和临床试验奠定基础。拟议的商业应用：开发激光手术来修复全层关节缺损将使数百万患有骨关节炎的人受益。这项技术可以为骨科医生提供新的技术，可以减少手术时间，恢复期和住院时间。