BIOLOGICAL NANOSTRUCTURES AND NANO-NETWORKS

生物纳米结构和纳米网络

• 批准号: 6420497
• 负责人: GLEN A EVANS
• 金额: $ 19.82万
• 依托单位: EGEA BIOSCIENCES, INC.
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-02-01 至 2003-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6420497
• 关键词: DNA; computer simulation; fluorescence; gene expression; genetic manipulation; mathematical model; microarray technology; nanotechnology; nucleic acid chemical synthesis; technology /technique development

Biological Nanostructures Nanotechnology is a critical field for the future of biomedicine and involves the creation of functional material, devices and systems through the control of matter at the scale of 1 to 100 nanometers. Physical techniques, such as atomic force and scanning tunneling microscopy, optical traps and tweezers, nanoscale carbon cones and bioactive nanotubes are only now becoming feasible. It is not yet possible, using these techniques, to routinely arrange individual atoms in space yielding new devices and materials. Biological systems, however, provide the capability of direct complex molecular assemblies and through the informational content of DNA allow access to the nanoscale world. The purpose of this project is to develop a technology for creating nanomaterials using engineered biological gene networks. The goal is to design genes and gene networks that will control the assembly of nanoscale structures. The technology will utilize: 1) the computer-aided design of large DNA molecules encoding series of interacting genes; 2) the complete chemical synthesis of these DNA molecules up to 10,000 base pairs using new core technology developed by Egea Biosciences. This project will carry out specific experiments to prove principle and provide demonstrations of the technology. PROPOSED COMMERCIAL APPLICATIONS. The work will result in novel genes that encode biochemical functions. This new technology would have applications in the development of medical diagnostics.

纳米技术是生物医学未来的关键领域，涉及通过控制1至100纳米尺度的物质来创建功能材料，设备和系统。物理技术，如原子力和扫描隧道显微镜，光学陷阱和镊子，纳米碳锥和生物活性纳米管现在才变得可行。目前还不可能使用这些技术在空间中常规地排列单个原子，从而产生新的设备和材料。然而，生物系统提供了直接复杂分子组装的能力，并通过DNA的信息内容允许进入纳米级世界。该项目的目的是开发一种利用工程生物基因网络制造纳米材料的技术。其目标是设计基因和基因网络，以控制纳米结构的组装。该技术将利用：1）计算机辅助设计编码一系列相互作用基因的大DNA分子; 2）使用Egea Biosciences开发的新核心技术完成这些DNA分子的化学合成，最多可达10，000个碱基对。该项目将进行具体的实验来证明原理并提供技术演示。建议的商业应用。这项工作将导致编码生物化学功能的新基因。这项新技术将应用于医学诊断的发展。