BREAST CANCER HYPOXIA ASSESSED BY NITRIC OXIDE
通过一氧化氮评估乳腺癌缺氧
基本信息
- 批准号:6514636
- 负责人:
- 金额:$ 10.34万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2001
- 资助国家:美国
- 起止时间:2001-07-16 至 2004-05-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
DESCRIPTION: (Applicant's Description)
It is our intent here to lay the groundwork for a translational study of the
efficacy of NIR optical method in deternining the level of hypoxia in human
breast cancer by NIR optical spectroscopy and imaging. The test requires a
gold standard of breast tumor hypoxia which is to be provided by pO2
deterninations where the instrumentation, expertise and technology is
available at the Leipzig University while the expertise and technology for NIR
spectroscopy and imaging is available at the University of Pennsylvania
affording an opportunity for translational research. It is our intent to
mobilize activities at these two locations in order that a initial test of 50
breast cancers can be made to validate that the spectroscopy and imaging of
breast tumor hypoxia gives values comparable to those obtained with the gold
standard of pO2 determination and that the
tumor localization is consistent with other modalities particularly
ultrasound, mammography and biopsy. Thus these studies require validation that
these two groups can work together; the Philadelphia group providing
instrumentation and personnel skilled in use of the instrumentation, whilst
the Leipzig group will provide not only expertise in pO2 determination,
ultrasound, biopsy, marnnography, but also the capability of making available
a large population of high risk breast cancer patients who are willing to
accept the complete protocol for breast cancer examinations. It is our intent
to provide two types of NIR information: I) localized and quantitative
spectroscopy of the desaturation of hemoglobin and the blood content in the
same breast canceri region as that in which the pO2 deternination takes place.
2) A NIR imaging system which gives rapid and effective imaging of the
deoxygenation of hemoglobin and blood concentration relative to nearby normal
breast tissue. While the pO2 determinations and NIR hemoglobin spectroscopy
and imaging currently afford the basis for calibration in models, the
comparative study has never been done before in human breast cancers. If
ourintended goals of demonstrating feasibility are achieved, then application
for support through regular RO1channels would appear to be justified.
描述:(申请人的描述)
我们在这里的目的是为翻译研究奠定基础,
近红外光学法测定人体缺氧水平的有效性
乳腺癌的近红外光谱和成像。测试需要一个
pO 2提供的乳腺肿瘤缺氧的金标准
仪器、专业知识和技术
而近红外光谱的专业知识和技术,
光谱学和成像技术在宾夕法尼亚大学
为转化研究提供了机会。我们的目的是
在这两个地点动员活动,以便在50个
乳腺癌可以用来验证
乳腺肿瘤缺氧给出的值与用金获得的值相当
pO 2测定标准,
肿瘤定位与其他方式一致,
超声波、乳房X光检查和活检。因此,这些研究需要验证,
这两个小组可以一起工作;费城小组提供
仪器和熟练使用仪器的人员,同时
莱比锡小组不仅将提供pO 2测定方面专门知识,
超声波,活检,mannography,但也有能力使可用
大量的高危乳腺癌患者愿意接受
接受完整的乳腺癌检查方案。我们的目的是
提供两种类型的NIR信息:I)局部和定量
血红蛋白的去饱和度和血液含量的光谱分析,
与pO 2测定发生的乳腺癌区域相同。
2)近红外成像系统,可快速有效地对物体进行成像
血红蛋白脱氧和相对于附近正常值的血液浓度
乳房组织虽然pO 2测定和近红外血红蛋白光谱
和成像目前提供了校准模型的基础,
以前从未在人类乳腺癌中进行过比较研究。如果
达到了论证可行性的预期目标,
通过常规RO 1渠道寻求支持似乎是合理的。
项目成果
期刊论文数量(1)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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BRITTON CHANCE其他文献
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{{ truncateString('BRITTON CHANCE', 18)}}的其他基金
WIDE BAND RECORDING OF BRAIN FUNCTIONAL ACTIVATION IN HUMANS
人类大脑功能激活的宽带记录
- 批准号:
7723792 - 财政年份:2008
- 资助金额:
$ 10.34万 - 项目类别:
WIDE BAND RECORDING OF BRAIN FUNCTIONAL ACTIVATION IN HUMANS
人类大脑功能激活的宽带记录
- 批准号:
7600796 - 财政年份:2007
- 资助金额:
$ 10.34万 - 项目类别:
ASSESSMENT OF MUSCLE VASCULAR DISEASE WITH DIFFUSE LIGHT
用漫射光评估肌肉血管疾病
- 批准号:
7357873 - 财政年份:2006
- 资助金额:
$ 10.34万 - 项目类别:
WIDE BAND RECORDING OF BRAIN FUNCTIONAL ACTIVATION IN HUMANS
人类大脑功能激活的宽带记录
- 批准号:
7357846 - 财政年份:2006
- 资助金额:
$ 10.34万 - 项目类别:
DEVELOPMENT OF NON-CONTACT MEDICAL IMAGING METHODS
非接触式医学成像方法的发展
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7183298 - 财政年份:2005
- 资助金额:
$ 10.34万 - 项目类别:
WIDE BAND RECORDING OF BRAIN FUNCTIONAL ACTIVATION IN HUMANS
人类大脑功能激活的宽带记录
- 批准号:
6977457 - 财政年份:2004
- 资助金额:
$ 10.34万 - 项目类别:
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