BREAST CANCER HYPOXIA ASSESSED BY NITRIC OXIDE

通过一氧化氮评估乳腺癌缺氧

基本信息

  • 批准号:
    6514636
  • 负责人:
  • 金额:
    $ 10.34万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2001
  • 资助国家:
    美国
  • 起止时间:
    2001-07-16 至 2004-05-31
  • 项目状态:
    已结题

项目摘要

DESCRIPTION: (Applicant's Description) It is our intent here to lay the groundwork for a translational study of the efficacy of NIR optical method in deternining the level of hypoxia in human breast cancer by NIR optical spectroscopy and imaging. The test requires a gold standard of breast tumor hypoxia which is to be provided by pO2 deterninations where the instrumentation, expertise and technology is available at the Leipzig University while the expertise and technology for NIR spectroscopy and imaging is available at the University of Pennsylvania affording an opportunity for translational research. It is our intent to mobilize activities at these two locations in order that a initial test of 50 breast cancers can be made to validate that the spectroscopy and imaging of breast tumor hypoxia gives values comparable to those obtained with the gold standard of pO2 determination and that the tumor localization is consistent with other modalities particularly ultrasound, mammography and biopsy. Thus these studies require validation that these two groups can work together; the Philadelphia group providing instrumentation and personnel skilled in use of the instrumentation, whilst the Leipzig group will provide not only expertise in pO2 determination, ultrasound, biopsy, marnnography, but also the capability of making available a large population of high risk breast cancer patients who are willing to accept the complete protocol for breast cancer examinations. It is our intent to provide two types of NIR information: I) localized and quantitative spectroscopy of the desaturation of hemoglobin and the blood content in the same breast canceri region as that in which the pO2 deternination takes place. 2) A NIR imaging system which gives rapid and effective imaging of the deoxygenation of hemoglobin and blood concentration relative to nearby normal breast tissue. While the pO2 determinations and NIR hemoglobin spectroscopy and imaging currently afford the basis for calibration in models, the comparative study has never been done before in human breast cancers. If ourintended goals of demonstrating feasibility are achieved, then application for support through regular RO1channels would appear to be justified.
描述:(申请人描述)

项目成果

期刊论文数量(1)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

BRITTON CHANCE其他文献

BRITTON CHANCE的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('BRITTON CHANCE', 18)}}的其他基金

WIDE BAND RECORDING OF BRAIN FUNCTIONAL ACTIVATION IN HUMANS
人类大脑功能激活的宽带记录
  • 批准号:
    7723792
  • 财政年份:
    2008
  • 资助金额:
    $ 10.34万
  • 项目类别:
WIDE BAND RECORDING OF BRAIN FUNCTIONAL ACTIVATION IN HUMANS
人类大脑功能激活的宽带记录
  • 批准号:
    7600796
  • 财政年份:
    2007
  • 资助金额:
    $ 10.34万
  • 项目类别:
ASSESSMENT OF MUSCLE VASCULAR DISEASE WITH DIFFUSE LIGHT
用漫射光评估肌肉血管疾病
  • 批准号:
    7357873
  • 财政年份:
    2006
  • 资助金额:
    $ 10.34万
  • 项目类别:
IN-MAGNET FUNCTIONAL MUSCLE IMAGING
磁内功能性肌肉成像
  • 批准号:
    7357864
  • 财政年份:
    2006
  • 资助金额:
    $ 10.34万
  • 项目类别:
WIDE BAND RECORDING OF BRAIN FUNCTIONAL ACTIVATION IN HUMANS
人类大脑功能激活的宽带记录
  • 批准号:
    7357846
  • 财政年份:
    2006
  • 资助金额:
    $ 10.34万
  • 项目类别:
BRAIN FUNCTIONAL IMAGING
脑功能成像
  • 批准号:
    7357865
  • 财政年份:
    2006
  • 资助金额:
    $ 10.34万
  • 项目类别:
DEVELOPMENT OF NON-CONTACT MEDICAL IMAGING METHODS
非接触式医学成像方法的发展
  • 批准号:
    7183298
  • 财政年份:
    2005
  • 资助金额:
    $ 10.34万
  • 项目类别:
IN MAGNET FUNCTIONAL MUSCLE IMAGING
磁体功能性肌肉成像
  • 批准号:
    6977456
  • 财政年份:
    2004
  • 资助金额:
    $ 10.34万
  • 项目类别:
NON-CONTACT FOREBRAIN IMAGING
非接触式前脑成像
  • 批准号:
    6976527
  • 财政年份:
    2004
  • 资助金额:
    $ 10.34万
  • 项目类别:
WIDE BAND RECORDING OF BRAIN FUNCTIONAL ACTIVATION IN HUMANS
人类大脑功能激活的宽带记录
  • 批准号:
    6977457
  • 财政年份:
    2004
  • 资助金额:
    $ 10.34万
  • 项目类别:

相似海外基金

FAIRClinical: FAIR-ification of Supplementary Data to Support Clinical Research
FAIRClinical:补充数据的 FAIR 化以支持临床研究
  • 批准号:
    EP/Y036395/1
  • 财政年份:
    2024
  • 资助金额:
    $ 10.34万
  • 项目类别:
    Research Grant
The IDeA State Consortium for a Clinical Research Resource Center: Increasing Clinical Trials in IDeA States through Communication of Opportunities, Effective Marketing, and WorkforceDevelopment
IDeA 州临床研究资源中心联盟:通过机会交流、有效营销和劳动力发展增加 IDeA 州的临床试验
  • 批准号:
    10715568
  • 财政年份:
    2023
  • 资助金额:
    $ 10.34万
  • 项目类别:
Optimizing integration of veterinary clinical research findings with human health systems to improve strategies for early detection and intervention
优化兽医临床研究结果与人类健康系统的整合,以改进早期检测和干预策略
  • 批准号:
    10764456
  • 财政年份:
    2023
  • 资助金额:
    $ 10.34万
  • 项目类别:
The Mayo Clinic NeuroNEXT Clinical Research Site
梅奥诊所 NeuroNEXT 临床研究网站
  • 批准号:
    10743328
  • 财政年份:
    2023
  • 资助金额:
    $ 10.34万
  • 项目类别:
Addressing Underperformance in Clinical Trial Enrollments: Development of a Clinical Trial Toolkit and Expansion of the Clinical Research Footprint
解决临床试验注册表现不佳的问题:开发临床试验工具包并扩大临床研究足迹
  • 批准号:
    10638813
  • 财政年份:
    2023
  • 资助金额:
    $ 10.34万
  • 项目类别:
The Minnesota TMD IMPACT Collaborative: Integrating Basic/Clinical Research Efforts and Training to Improve Clinical Care
明尼苏达州 TMD IMPACT 协作:整合基础/临床研究工作和培训以改善临床护理
  • 批准号:
    10828665
  • 财政年份:
    2023
  • 资助金额:
    $ 10.34万
  • 项目类别:
Improving Multicultural Engagement in Clinical Research through Partnership with Federally Qualified Health Centers and Community Health Worker Programs
通过与联邦合格的健康中心和社区卫生工作者计划合作,改善临床研究中的多元文化参与
  • 批准号:
    10823828
  • 财政年份:
    2023
  • 资助金额:
    $ 10.34万
  • 项目类别:
Promoting a Culture Of Innovation, Mentorship, Diversity and Opportunity in NCI Sponsored Clinical Research: NCI Research Specialist (Clinician Scientist) Award Application of Janice M. Mehnert, M.D.
在 NCI 资助的临床研究中促进创新、指导、多样性和机会文化:Janice M. Mehnert 医学博士的 NCI 研究专家(临床科学家)奖申请
  • 批准号:
    10721095
  • 财政年份:
    2023
  • 资助金额:
    $ 10.34万
  • 项目类别:
Clinical Research Center for REstoration of NEural-based Function in the Real World (RENEW)
现实世界神经功能恢复临床研究中心 (RENEW)
  • 批准号:
    10795328
  • 财政年份:
    2023
  • 资助金额:
    $ 10.34万
  • 项目类别:
Clinical Research and Academic Success in Obstetrics & Gynecology
产科临床研究和学术成就
  • 批准号:
    10828252
  • 财政年份:
    2023
  • 资助金额:
    $ 10.34万
  • 项目类别:
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了