ROLE OF CD4+ TH1 LYMPHOCYTES IN PROTECTION AGAINST EIAV

CD4 TH1 淋巴细胞在预防 EIAV 中的作用

基本信息

  • 批准号:
    6511292
  • 负责人:
  • 金额:
    $ 21.75万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2001
  • 资助国家:
    美国
  • 起止时间:
    2001-05-01 至 2004-04-30
  • 项目状态:
    已结题

项目摘要

DESCRIPTION: (Adapted from Applicant's Abstract) Identification of immune responses that can help control equine infectious anemia virus (EIAV) seems important because similar mechanisms may be applicable to other lentivirus infections. Reasons for assuming that immunological responses involved in protection against EIAV can be identified are based on eventual control of the disease in horses and on the demonstration that lymphocyte responses are responsible for the control. The decrease of initial plasma viremia to undetectable levels in infected horses is associated with the appearance of CD8+ cytotoxic T lymphocytes (CTL), while neutralizing antibody often is undetectable until after clearance of the plasma viremia. The requirement for pathogen-specific CD4+ helper T lymphocyte (HTL) activity of the Th1 subset, as determined by cytokine production, for effective CTL responses is well documented. In addition, there are studies in different viral systems that demonstrate the efficacy of using only HTL epitopes that elicit a strong CD4+ Th1 response to enhance both proliferative and CTL activity upon subsequent virus challenge. Such an approach for lentivirus vaccines might overcome the difficulty of identifying both universal CTL and HTL epitopes which are presented by a broad range of major histocompatibility complex class I or class II molecules, respectively. This is because there is evidence indicating that such universal HTL epitopes may be more common than universal CTL epitopes. Further, HTL epitopes have been located in conserved regions of lentiviruses possibly circumventing another key problem of antigenic variation. Our long-term research goal is to determine the roles of HTL and CTL in the control of lentiviral infections and to achieve this goal we particularly need more knowledge of the contribution of CD4+ T lymphocytes to this immunity. To that end, the experiments outlined in this proposal will directly test the hypothesis that induction of CD4+ Th1 lymphocyte responses to universal and conserved EIAV epitopes will promote enhanced CTL responses to, and afford protection against, subsequent EIAV challenge.
描述:(改编自申请人的摘要) 可以帮助控制马传染性贫血病毒(EIAV)的反应似乎 重要是因为类似的机制可能适用于其他慢病毒 感染.假设免疫反应涉及 对EIAV的保护可以确定是基于对EIAV的最终控制, 马的疾病,并证明淋巴细胞反应是 负责控制。初始血浆病毒血症降低至 感染马中检测不到的水平与以下症状的出现有关: CD8+细胞毒性T淋巴细胞(CTL),而中和抗体通常是 直到血浆病毒血症清除后才能检测到。的要求 Th1亚群的病原体特异性CD4+辅助性T淋巴细胞(HTL)活性, 通过细胞因子的产生来确定,有效的CTL应答是良好的。 记录在案。此外,在不同的病毒系统中有研究表明, 证明仅使用HTL表位的有效性,HTL表位引发强的CD4+ T细胞亚群。 Th1应答增强增殖和CTL活性, 病毒挑战这种慢病毒疫苗的方法可能会克服 难以鉴定通用CTL和HTL表位, 由广泛的主要组织相容性复合体I类或I类 II分子。这是因为有证据表明, 这种通用HTL表位可能比通用CTL表位更常见。 此外,HTL表位已定位于慢病毒的保守区域中 这可能会避免另一个关键的抗原变异问题。我们 长期的研究目标是确定HTL和CTL在控制中的作用, 为了实现这一目标,我们特别需要更多的 了解CD4+ T淋巴细胞对这种免疫力的贡献。与 最后,本提案中概述的实验将直接测试 假设诱导CD4+ Th1淋巴细胞对通用和 保守的EIAV表位将促进增强的CTL应答, 保护免受随后的EIAV挑战。

项目成果

期刊论文数量(0)
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科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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Travis C. McGuire其他文献

Molecular cloning of a gene encoding the immunogenic 21 kDa protein of Cowdria ruminantium.
编码 Cowdria ruminantium 免疫原性 21 kDa 蛋白的基因的分子克隆。
  • DOI:
  • 发表时间:
    1994
  • 期刊:
  • 影响因子:
    1.5
  • 作者:
    S. Mahan;Travis C. McGuire;S. Semu;M. V. Bowie;Frans Jongejan;F. R. Rurangirwa;A. Barbet
  • 通讯作者:
    A. Barbet
Differentiation of F38 mycoplasmas causing contagious caprine pleuropneumonia with a growth-inhibiting monoclonal antibody
使用生长抑制单克隆抗体分化引起传染性山羊胸膜肺炎的 F38 支原体
  • DOI:
    10.1128/iai.55.12.3219-3220.1987
  • 发表时间:
    1987
  • 期刊:
  • 影响因子:
    3.1
  • 作者:
    F. R. Rurangirwa;Travis C. McGuire;Anthony J. Musoke;A. Kibor
  • 通讯作者:
    A. Kibor
Hypogammaglobulinemia predisposing to infection in foals.
低丙种球蛋白血症容易导致马驹感染。
Arabian horses with severe combined immunodeficiency — evaluation of functional thymic hormones
  • DOI:
    10.1016/s0145-305x(79)80031-2
  • 发表时间:
    1979-01-01
  • 期刊:
  • 影响因子:
  • 作者:
    Gary A. Splitter;Genevieve S. Incefy;Mireille Dardenne;Tsutomu Iwata;Travis C. McGuire
  • 通讯作者:
    Travis C. McGuire
The detection of precipitating antibodies in equine infectious anemia and partial purification of the antigen
  • DOI:
    10.1007/bf01241919
  • 发表时间:
    1971-12-01
  • 期刊:
  • 影响因子:
    2.500
  • 作者:
    James B. Henson;Travis C. McGuire;John R. Gorham
  • 通讯作者:
    John R. Gorham

Travis C. McGuire的其他文献

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{{ truncateString('Travis C. McGuire', 18)}}的其他基金

EIAV vector targeting dendritic cells to induce CTL
EIAV载体靶向树突状细胞诱导CTL
  • 批准号:
    6843663
  • 财政年份:
    2004
  • 资助金额:
    $ 21.75万
  • 项目类别:
ROLE OF CD4+ TH1 LYMPHOCYTES IN PROTECTION AGAINST EIAV
CD4 TH1 淋巴细胞在预防 EIAV 中的作用
  • 批准号:
    6312475
  • 财政年份:
    2001
  • 资助金额:
    $ 21.75万
  • 项目类别:
IMMUNOLOGY TRAINING PROGRAM
免疫学培训计划
  • 批准号:
    2875361
  • 财政年份:
    1989
  • 资助金额:
    $ 21.75万
  • 项目类别:
IMMUNOLOGY TRAINING PROGRAM
免疫学培训计划
  • 批准号:
    6169477
  • 财政年份:
    1989
  • 资助金额:
    $ 21.75万
  • 项目类别:
IMMUNOLOGY TRAINING PROGRAM
免疫学培训计划
  • 批准号:
    6372738
  • 财政年份:
    1989
  • 资助金额:
    $ 21.75万
  • 项目类别:
IMMUNOLOGY TRAINING PROGRAM
免疫学培训计划
  • 批准号:
    3530673
  • 财政年份:
    1989
  • 资助金额:
    $ 21.75万
  • 项目类别:
IMMUNOLOGY TRAINING PROGRAM
免疫学培训计划
  • 批准号:
    2057814
  • 财政年份:
    1989
  • 资助金额:
    $ 21.75万
  • 项目类别:
IMMUNOLOGY TRAINING PROGRAM
免疫学培训计划
  • 批准号:
    2671492
  • 财政年份:
    1989
  • 资助金额:
    $ 21.75万
  • 项目类别:
IMMUNOLOGY TRAINING PROGRAM
免疫学培训计划
  • 批准号:
    2390123
  • 财政年份:
    1989
  • 资助金额:
    $ 21.75万
  • 项目类别:
IMMUNOLOGY TRAINING PROGRAM
免疫学培训计划
  • 批准号:
    2057816
  • 财政年份:
    1989
  • 资助金额:
    $ 21.75万
  • 项目类别:

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