Engineering an Escherichia coli chassis strain to produce heterologous antigen-containing outer membrane vesicles for use as a novel mucosal vaccine p

工程化大肠杆菌底盘菌株以产生含有异源抗原的外膜囊泡，用作新型粘膜疫苗

• 批准号: 2103848
• 金额: --
• 依托单位: University of Nottingham
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2018
• 资助国家: 英国
• 起止时间: 2018 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2103848
• 关键词: Engineering; Escherichia; coli; chassis; strain

Hyper-vesiculating E.coli will be engineered to produce outer membrane vesicles (OMVs) containing antigens from Clostridium difficile. These OMVs will be tested for their protective efficacy against C. diff infection in relevant animal models.

超水泡大肠杆菌将被改造成生产含有艰难梭菌抗原的外膜囊泡(OMV)。这些OMV将在相关动物模型中测试其对C.diff感染的保护效果。