ALCOHOLISM--EPIDEMIOLOGIC HIGH RISK FAMILY STUDY

酗酒--流行病学高危家庭研究

• 批准号: 6563228
• 负责人: KATHLEEN KEENAN BUCHOLZ
• 金额: $ 17.85万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-01-01 至 2002-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6563228
• 关键词: adolescence (12-20); alcoholism /alcohol abuse; behavioral /social science research tag; clinical research; comorbidity; family genetics; genetic susceptibility; human subject; interview; longitudinal human study; mental disorder diagnosis; parent offspring interaction; peer group; questionnaires; siblings; social support network; substance abuse epidemiology; young adult human (21-34)

This project represents a new paradigm for epidemiologic research on alcoholism: it nests a high risk genetic/family study within an epidemiologic framework. Advantages over existing studies are: ascertainment of families from a representative sample; systemic selection of families at high and low risk of alcoholism; direct assessments of multiple family members, including up to 3 offspring and parents; longitudinal follow-up of the offspring; over-sample of minority families; and collection of DNA for future assessments of genetic risk/protective factors. This design permits testing of hypothesis relating to sibling and peer influences on adolescent/young adult alcohol problems, which more conventional parents-one child designs, and even more specialized twin-family designs, may tested in a limited way. Families are ascertained through birth records of adolescents and young adults born in Missouri (ensuring comparability with Project 1), and biological mothers administered a telephone screening interview to identify potentially high risk families. All families screening positive, and a subsample of those screening negative will be invited for the second stage, where biological mothers and fathers (or best informant) will be administered a telephone diagnostic interview and question to assess own and co-parent's history of DSM-I alcohol abuse or dependent, as well as history of behavioral and emotional problems of the proband and up to 2 siblings aged 13-25. Probands and up to 2 of their siblings from families where fathers were reported by mothers to have 3 or more symptoms of alcohol dependence ("high risk", 100 AA, 100 W) and those from families where fathers were not so reported, or who screened negative ("controls": 150 AA, 150 W) will be invited for telephone diagnostic interview at baseline and again at 2 years, with brief telephone diagnostic interview at baseline and again at 2 years, with brief telephone follow up interviews in other years along with annual questionnaire assessments. Data will be used to test hypotheses about (i) sibling and peer influences on alcohol and other substance involvement and problems, (ii) relationships between parenting style, parental alcoholism and co-morbidity, and offspring alcoholism, (iii) relationships between co-morbidity, temperament, traumatic events and this chronic stress, and offspring alcoholism, and (iv) the modification of these relationships by ethnicity. Results from this project will provide an important check on the generalizability of finds from other projects that rely upon specialized twin-family designs.

该项目代表了酗酒流行病学研究的新范式：它在流行病学框架内嵌套了高风险遗传/家族研究。与现有研究相比，其优势在于：从具有代表性的样本中确定家庭;系统选择酗酒高风险和低风险的家庭;直接评估多个家庭成员，包括多达3个后代和父母;对后代进行纵向随访;对少数民族家庭进行过度抽样;收集DNA用于未来遗传风险/保护因素的评估。这种设计允许测试的假设有关的兄弟姐妹和同龄人的影响，青少年/年轻的成年人的酒精问题，更传统的父母一个孩子的设计，甚至更专业的双胞胎家庭的设计，可以在有限的方式进行测试。通过在密苏里州出生的青少年和年轻人的出生记录（确保与项目1的可比性）确定家庭，并对亲生母亲进行电话筛查面谈，以确定潜在的高风险家庭。所有筛查阳性的家庭和筛查阴性的子样本将被邀请参加第二阶段，其中亲生母亲和父亲（或最佳信息提供者）将接受电话诊断访谈和问题，以评估自己和共同父母的DSM-I酒精滥用或依赖史，以及先证者和最多2名13-25岁兄弟姐妹的行为和情感问题史。先证者和来自父亲被母亲报告有3种或3种以上酒精依赖症状的家庭的最多2名兄弟姐妹（“高风险”，100 AA，100 W）和来自父亲未被如此报告的家庭的儿童，或筛查呈阴性的儿童，（“控制”：150 AA，150 W）将被邀请在基线时和第2年时再次进行电话诊断访谈，在基线时和第2年时再次进行简短的电话诊断访谈，在其他年份进行简短的电话随访，沿着年度问卷评估。数据将被用来测试假设（一）兄弟姐妹和同龄人对酒精和其他物质的参与和问题的影响，（二）养育方式，父母酗酒和共病，后代酗酒之间的关系，（三）共病，气质，创伤事件和这种慢性压力，后代酗酒之间的关系，以及（四）种族对这些关系的修改。这个项目的结果将提供一个重要的检查，从其他项目，依赖于专门的双家庭设计的发现的普遍性。