Resource Core

资源核心

• 批准号: 7555150
• 负责人: KATHLEEN KEENAN BUCHOLZ
• 金额: $ 12.38万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-30 至 2014-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7555150
• 关键词: Alcoholism; Algorithms; Area; Arts; CCL7 gene; Comorbidity; Consultations; Data; Data Base Management; Data Collection; Data Set; Databases; Development; Diagnosis; Diagnostic; Disease; Ensure; Environment; Environmental Risk Factor; Etiology; Faculty; Family; Future; General Population; Genes; Genotype; Goals; Human; Individual; Information Systems; Interview; Investigation; Laboratory Research; Light; Maintenance; Management Information Systems; Measurement; Measures; Mentors; Missouri; Modality; Monitor; Online Systems; Participant; Personal Digital Assistant; Phenotype; Pilot Projects; Play; Population Database; Positioning Attribute; Process; Productivity; Protocols documentation; Questionnaires; Research; Research Design; Research Infrastructure; Research Personnel; Research Project Grants; Research Support; Resources; Risk; Role; Sampling; Schedule; Science; Series; Surveys; System; Time; Training; Work; alcohol research; base; career; experience; follow-up; genome wide association study; novel

The Science Resource Core (SRC) has emerged as an independent core for years 11-15 of the MARC, in recognition of the cross-cutting activities reflected in the 4 proposed Research Projects and pilot studies, and in the series of related R01 studies. The overarching goal of the SRC is to provide important infrastructure support and assessment coordination for Center-based and Center-affiliated research, through three broad aims: (1) general population database management and manipulation in support of subject ascertainment, follow-up, and novel study design thru the Missouri Family Register ("MFR"); (2) phenotype, environmental and genotype information management systems ("PEGIMS") which include harmonization across studies of diagnostic phenotypes and environmental risk exposures, creation of centralized databases for these, and a central database of the genotypic data collected in the Center projects; and (3) continuation of assessment coordination and consultation ("ACC") to ensure compatibility of measurements across the range of human research (laboratory, experimental, survey) and modalities (palm pilot, web-based, interview, questionnaire) to facilitate cross-study analysis, a line of research that is particularly compelling in the era of Genome-wide association studies and the concomitant requirement of huge samples. Core resources are essential to the current Center-based and Center-related projects, encompassing important research support features hat would not be feasible for individual investigators to obtain on their own. The Core takes advantage of the Center's interdisciplinary scientific group for coordination and harmonization functions. The core also serves an important training and faculty development purpose by providing resources important to junior investigators as they seek to establish independent careers in alcohol research. Resources managed and maintained in the SRC uniquely position the Center to continue its work of shedding light on the risk processes in the development of alcoholism and comorbid phenotypes by facilitating: informative sampling from the general population; cross study analyses of gene-environment interplay over time in different samples with coordinated diagnoses and environmental risk exposures; and continued maintenance of coordinated assessments across studies for future investigation and cross-study analyses.

科学资源核心 (SRC) 已成为 MARC 第 11-15 年的独立核心， 认可 4 个拟议研究项目和试点研究中反映的跨领域活动，以及 在一系列相关的 R01 研究中。 SRC 的总体目标是提供重要的基础设施 通过三个广泛的领域，对中心和中心附属研究提供支持和评估协调 目标：（1）一般人群数据库管理和操作以支持主题确定， 通过密苏里州家庭登记处（“MFR”）进行后续和新颖的研究设计； (2)表型、环境 和基因型信息管理系统（“PEGIMS”），其中包括跨研究的协调 诊断表型和环境风险暴露，为这些创建集中数据库，以及 中心项目中收集的基因型数据的中央数据库； (3) 继续评估 协调和咨询（“ACC”），以确保测量在人类范围内的兼容性 研究（实验室、实验、调查）和方式（掌上电脑试点、基于网络、访谈、问卷调查） 促进交叉研究分析，这是在全基因组时代特别引人注目的一系列研究 关联研究以及随之而来的大量样本的要求。核心资源对于 目前以中心为基础和与中心相关的项目，包括重要的研究支持功能 个别调查人员无法自行获得。核心利用了 中心的跨学科科学小组负责协调和统一职能。核心还服务于 通过提供对初级学生重要的资源来实现重要的培训和教师发展目的 研究人员寻求在酒精研究领域建立独立的职业生涯。资源管理和 SRC 保持独特地位，使该中心能够继续开展揭示风险的工作 通过以下方式促进酒精中毒和共病表型的发展过程： 信息采样 来自一般人群；不同时期基因与环境相互作用的交叉研究分析 具有协调诊断和环境风险暴露的样本；并持续维护 协调跨研究的评估，以供未来调查和交叉研究分析。