Catalytic Enantioselective 1,2-Rearrangements Using Lewis Base Catalysis

使用路易斯碱催化的催化对映选择性 1,2-重排

• 批准号: 2104946
• 金额: --
• 依托单位: University of St Andrews
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2018
• 资助国家: 英国
• 起止时间: 2018 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2104946
• 关键词: Catalytic; Enantioselective; Rearrangements; Using; Lewis

The development of efficient catalytic enantioselective methods to prepare enantiomerically pure bespoke a-amino acid derivatives from cheap, readily available and sustainable chemical building blocks is a significant challenge for the fine chemical industry. Inspired by this need, this project aims to develop versatile and state-of-the-art methodologies for the catalytic enantioselective synthesis of functionalised a-amino acids. This project will provide state-of-the-art solutions to the catalytic enantioselective synthesis of functionalised a-amino acid derivatives through the [1,2]-rearrangement of allylic ammonium ylides. Combined with kinetic and mechanistic studies this will provide a stimulating and challenging CRITICAT PhD project.

开发高效的催化对映选择性方法，从廉价、易得和可持续的化学构件中制备对映体纯的定制a-氨基酸衍生物，是精细化学工业面临的重大挑战。在这一需求的启发下，本项目旨在开发多功能和最先进的方法，用于催化对映体选择性合成功能化的α-氨基酸。该项目将通过烯丙基叶立德的[1，2]-重排反应，为催化对映体选择性合成功能化α-氨基酸衍生物提供最先进的解决方案。结合动力学和机械学研究，这将提供一个刺激和具有挑战性的CRITICAT博士项目。