Catalytic Enantioselective 1,2-Rearrangements Using Lewis Base Catalysis

开发高效的催化对映选择性方法，从廉价、易得和可持续的化学构件中制备对映体纯的定制a-氨基酸衍生物，是精细化学工业面临的重大挑战。在这一需求的启发下，本项目旨在开发多功能和最先进的方法，用于催化对映体选择性合成功能化的α-氨基酸。该项目将通过烯丙基叶立德的[1，2]-重排反应，为催化对映体选择性合成功能化α-氨基酸衍生物提供最先进的解决方案。结合动力学和机械学研究，这将提供一个刺激和具有挑战性的CRITICAT博士项目。

The development of efficient catalytic enantioselective methods to prepare enantiomerically pure bespoke a-amino acid derivatives from cheap, readily available and sustainable chemical building blocks is a significant challenge for the fine chemical industry. Inspired by this need, this project aims to develop versatile and state-of-the-art methodologies for the catalytic enantioselective synthesis of functionalised a-amino acids. This project will provide state-of-the-art solutions to the catalytic enantioselective synthesis of functionalised a-amino acid derivatives through the [1,2]-rearrangement of allylic ammonium ylides. Combined with kinetic and mechanistic studies this will provide a stimulating and challenging CRITICAT PhD project.