CORE--CLINICAL BIOCHEMISTRY FACILITY

临床生物化学设施的目的是为临床化学和生物化学流行病学提供质量控制分析，以及为AHFCC科学家和项目提供临床协调和生物样本收集和储存。该设施位于两个实验室（总面积约670平方米）内。在内勒达纳研究所第二单元。该设施的工作人员包括设施负责人，John P. Richie, Jr.，博士（10%的努力），实验室主管，Steven Colosimo，硕士（100%的努力），临床化学家，Allison Muir，学士（100%的努力）和临床协调员，Laura Tolosi, m.s.， R.D.（40%的努力）。该设施的主要资源包括一台Johnson & Johnson Vitros 500大型机临床化学分析仪，几台便携式临床化学分析仪，Dynatech 5000 96孔板领导者与Biolinx软件，闪烁计数器，高效液相色谱，气相色谱，自动分析仪和自动血液分析仪。该设施提供常规临床化学分析和免疫分析，以及使用充电回退机制的专业生物化学和生物标志物测试。此外，该机构还参与了用于大规模人体研究的生物标志物开发。我们还通过提供临床协调和生物样本收集和储存方面的专业知识来支持人体研究的实施。癌症中心的专业知识对于临床研究的实施至关重要，特别是在需求明显增加的梅勒达纳研究所。特别重要的是，该设施在涉及DNA分析的人类研究的保密问题上提供协助。该设施为所有核心支持的项目以及AHFCC和其他设施内的非编程对齐项目提供服务。每年大约有10-15名同行资助的AHF研究人员以及12-18名外部科学家使用该设施，每年分析约5,000至10,000个样本。在过去的一年中，该设施的总使用量中有90%是由AHFCC成员的同行评审资助的项目使用的。

The purpose of the Clinical Biochemistry Facility is to provide quality controlled analyses for clinical chemistry and biochemical epidemiology as well as clinical coordination and biological sample collection and banking for AHFCC scientists and projects. The facility is located in two laboratories (combined space of approximately 670 sq. ft) in Unit 2 at the Naylor Dana Institute. The facility is staffed by a facility head, John P. Richie, Jr., Ph.D. (10% effort), a lab supervisor, Steven Colosimo, MS. (100% effort), a clinical chemist, Allison Muir, B.S. (100% effort), and a clinical coordinator, Laura Tolosi, M.S., R.D. (40% effort). The major resources of the facility include a Johnson & Johnson Vitros 500 Mainframe Clinical Chemistry Analyzer, several portable clinical chemistry analyzers, Dynatech 5000 96 well plate leader with Biolinx software, scintillation counters, HPLCs, GC, auto analyzers and a automated hematological analyzer. The facility offers routine clinical chemistry assays and immunoassays as well as specialized biochemistry and biomarkers tests using a charge-back mechanism. In addition, the facility is involved in biomarker development for use in large-scale human studies. We also support the implementation of human studies by providing expertise in clinical coordination and biological samples collection and banking. This expertise within the Cancer Center is essential for the implementation of clinical studies, particularly at the Maylor Dana Institute where an increasing demand is evident. Of particular important, the facility provides assistance with confidentiality issues especially in human studies involving DNA analysis. This facility provides services to all of the Core-supported programs as well as to non-programmatically aligned programs within AHFCC and at other facilities. Approximately 10-15 peer funded investigators at AHF as well as 12-18 external scientists make use of the facility each year for a total of about 5,000 to 10,000 samples assayed per year. Over the past year, > 90% of the total use of the facility was by AHFCC members' peer- reviewed funded projects.