RANDOMIZED SLOW FLUORIDE TRIAL IN IDIOPATHIC OSTEOPOROSIS

本研究的总体目标是确定治疗是否 与SR-NaF将纠正潜在的障碍，并在临床上 用于特发性骨质疏松症，通过进行安慰剂对照 随机试验 这项试验的目的是验证 一项非随机试验表明SR-NaF治疗在临床上有效， 在这种情况下安全。 第二个目标是确定 特发性骨质疏松症的骨形成缺陷可能是由于 成骨细胞生长因子合成受损，如果治疗 SR-NaF可纠正成骨细胞功能紊乱。从 从服用SR-NaF或 将检查松质骨的生长合成 因素

The overall goal of this study is to ascertain whether the treatment with SR-NaF would correct the underlying disturbance and be clinically useful in idiopathic osteoporosis, by conducting a placebo-controlled randomized trial. The goal of this trial is to validate findings from a non-randomized trial that SR-NaF treatment is clinically effective and safe in this condition. A secondary goal is to ascertain whether the defective bone formation in idiopathic osteoporosis might be due to impaired osteoblastic synthesis of growth factors, and if the treatment with SR-NaF might correct the disturbance in osteoblastic function. From bone biopsies procured from selected patient taking eith SR-NaF or placebo, cancellous bone will be examined for the synthesis of growth factors.