CAUSES AND MANAGEMENT OF PRIMARY HYPERCHOLESTEROLEMIA

原发性高胆固醇血症的原因和治疗

• 批准号: 6567641
• 负责人: Scott M. Grundy
• 金额: $ 32.14万
• 依托单位: UT SOUTHWESTERN MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-12-01 至 2002-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6567641
• 关键词: antihyperlipoproteinemic agent; blood disorder chemotherapy; blood lipoprotein metabolism; clinical research; combination therapy; diet therapy; dietary lipid; drug adverse effect; drug screening /evaluation; human subject; human therapy evaluation; hypercholesterolemia; low density lipoprotein; metabolism disorder chemotherapy; nutrition related tag; very low density lipoprotein

This NIH project examines lipoprotein defects, evaluates clinical significance and the need to treat. Treatment options under investigation include role of individual dietary fatty acids and the mode of action, safety and efficacy of single and combined drug therapy. Metabolic unit studies are conducted as well as kinetic studies. Metabolism and underlying defects in lipoproteins are being minutely analysed. Source of research material is plasma lipoproteins throughout the different study phases. LDL/VLDL turnover studies will be utilized.

这个NIH项目检查脂蛋白缺陷，评估临床