Development of nanotechnology tools for real-time health care diagnostics

开发用于实时医疗保健诊断的纳米技术工具

• 批准号: 2105921
• 金额: --
• 依托单位: University of Southampton
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2018
• 资助国家: 英国
• 起止时间: 2018 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2105921
• 关键词: Development; nanotechnology; tools; real; time

We aim to develop nanotechnology tools for real-time health care diagnostics to improve diagnostics of osteoarthritis and cancer. Based on the indentation type atomic force microscopy (IT-AFM) technology that my team and I developed over the last 20 years, we are now taking the next steps by targeting different health applications with connection to digitization and the Internet of Things (IoT). A first application of the IT-AFM technology is the development of osteoarthritis (OA) drugs to drastically reduce the need of knee and hip joint implants. There are no OA drugs, because there are no sensitive tools to detect the structure-modifying effects of substances in articular cartilage in animal testing and in patients. A drug that could delay the time to surgery by only one year would be a huge market. As a second application the IT-AFM technology may be employed to quickly decide if a tumor is malignant or benign. In such scenario, a tumor biopsy is taken in the operation theatre and placed into the desktop analysis tool. Digital data is exchanged real-time with a reference laboratory that can quickly evaluate if a biopsy is malignant or benign. The IT-AFM technology may improve cancer diagnostics and prognosis and contribute to the development of personalized therapies. Such progress in medicine would save money and time and provide the surgeon with information for instant informed clinical decision making. The IT-AFM technology is scalable and can be expanded to a variety of biomedical and technical applications including the development of custom-made commercial products for specialized applications. We have developed the IT-AFM technology and published it in three landmark papers including an article in Nature Nanotechnology. We are currently evaluating different possible collaborations with our local partners and partners worldwide to find the best match for this work. Depending on the collaboration and in agreement with our partners and the students abilities, we will then how the Ph.D. student best fit our team.

我们的目标是开发用于实时医疗保健诊断的纳米技术工具，以改善骨关节炎和癌症的诊断。基于我和我的团队在过去20年中开发的压痕型原子力显微镜（IT-AFM）技术，我们现在正在采取下一步行动，针对不同的健康应用与数字化和物联网（IoT）相连接。IT-AFM技术的第一个应用是开发骨关节炎（OA）药物，以大幅减少膝关节和髋关节植入物的需求。没有OA药物，因为没有敏感的工具来检测动物试验和患者关节软骨中物质的结构修饰作用。一种能将手术时间推迟一年的药物，将是一个巨大的市场。作为第二种应用，IT-AFM技术可用于快速确定肿瘤是恶性还是良性。在这种情况下，肿瘤活检在手术室中进行，并放置在桌面分析工具中。数字数据与参考实验室实时交换，可以快速评估活检是恶性还是良性。IT-AFM技术可以改善癌症诊断和预后，并有助于个性化治疗的发展。医学的这种进步将节省金钱和时间，并为外科医生提供即时知情的临床决策信息。IT-AFM技术是可扩展的，可以扩展到各种生物医学和技术应用，包括为专门应用开发定制的商业产品。我们已经开发了IT-AFM技术，并在三篇具有里程碑意义的论文中发表，其中包括Nature Nanotechnology上的一篇文章。我们目前正在评估与我们的本地合作伙伴和全球合作伙伴的不同可能的合作，以找到这项工作的最佳匹配。根据合作，并与我们的合作伙伴和学生的能力，我们将如何博士。学生最适合我们的团队。