Chemical Synthesis and Biological evaluation of improved PROTACS based on a novel Design Strategy

该项目涉及一种新的方法来优化相对较新的一类生物活性化合物PROTAC的活性和物理性质，PROTAC目前对实现靶向蛋白质降解具有巨大的兴趣。有机化学方面包括一系列氟化前体的化学合成，然后并入PROTAC。药物化学方面包括在我们的工业合作者阿斯利康放置时对合成的PROTAC与一组医学相关蛋白质的评价。该项目源于世界领先的有机氟药物化学专业知识。虽然合成有机化学是该项目的一个关键方面，但它包含强大的药物化学元素，您将熟悉药物在当前药物优化中的重要作用。您将熟悉PROTAC在当前药物优化中的重要作用以及PROTAC的新兴领域

The project concerns a novel approach to optimise the activity and physical properties of a relatively new class of bioactive compounds, PROTACs, which are of huge current interest to achieve targeted protein degradation. The organic chemistry aspect consists of the chemical synthesis of a series of fluorinated precursors followed by incorporation into PROTACs. The medicinal chemistry aspect consists of the evaluation of the synthesised PROTACs against a panel of medically relevant proteins while on placement at our industrial collaborator, AstraZeneca. The project originates from the world-leading expertise in organofluorine medicinal chemistry. While synthetic organic chemistry is a key aspect of the project, it contains a strong medicinal chemistry element, and you will become familiar with the significant role of fluorination in current drug optimisation While synthetic organic chemistry is a key aspect of the project, it contains a strong medicinal chemistry element, and you will become familiar with the significant role of fluorination in current drug optimisation and with the burgeoning field of PROTACs