Chemical Synthesis and Biological Evaluation of Analogues of Platencin, a New-generation Antibiotic

新一代抗生素Platencin类似物的化学合成及生物学评价

• 批准号: LP0990498
• 负责人: Prof Martin Banwell
• 金额: $ 20.8万
• 依托单位: The Australian National University
• 依托单位国家: 澳大利亚
• 项目类别: Linkage Projects
• 财政年份: 2010
• 资助国家: 澳大利亚
• 起止时间: 2010-10-01 至 2014-04-24
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/LP0990498
• 关键词: Chemical; Synthesis; Biological; Evaluation; Analogues

The just discovered natural product platencin displays potent and broad spectrum anti-bacterial activity. It may represent the precursor of a new class of drugs to replace current anti-infective agents which are becoming alarmingly less effective as bacterial resistance increases dramatically. For this reason, platencin has been described as a once in a generation discovery. This study will exploit two sophisticated new synthetic techniques for the purposes of making analogues of platencin that will be screened by the industry partner, Biota, for anti-bacterial properties. New drug candidates capable of treating especially dangerous infections such as methicillin resistant staphyllococcus aureus (MRSA) should thus emerge.

新发现的天然产物铂素具有较强的广谱抗菌活性。它可能代表着一种新型药物的先驱，以取代目前的抗感染药物，随着细菌耐药性的急剧增加，抗感染药物的效果正在变得令人担忧地变得不那么有效。出于这个原因，铂被描述为一代人只有一次的发现。这项研究将利用两种复杂的新合成技术来制造铂素的类似物，行业合作伙伴Biota将对其进行抗菌性能筛选。因此，应该出现能够治疗特别危险的感染的新候选药物，如耐甲氧西林金黄色葡萄球菌(MRSA)。