QUALITY OF LIFE

我们的主要目标是只评估对癌症患者和临床实践有实际结果的相关终点。在过去的资助期间，QOL研究已被组织成一个程序化的方法，遵循三个主题：1）在治疗试验中有效评估QOL终点; 2）设计专门针对QOL终点的试验; 3）开发新的QOL方法。通过直接干预影响QOL终点、改善QOL评估方法或干预改善伴随副作用，可以改善癌症治疗交付。发展这些研究工作的一个障碍是缺乏专用资源。前期工作：我们前期工作的一个指导原则可以概括为“少即是多”。 我们证明了一个单项的整体生活质量工具可以显示出比针对同一结构的多项工具更大的变化灵敏度。我们使用最低限度足够的个人生活质量项目集和先前的临床显著效应量。前期工作：我们前期工作的一个指导原则可以概括为“少即是多”。“我们证明了一个单一项目的全球QOL工具可以显示出比针对同一结构的多项目工具更大的变化敏感性。我们使用最低限度的充分集的个人生活质量项目和先验的临床显着的效果大小。临床试验工作包括针对QOL终点（如社会支持）的试点研究，这些终点直接影响接受和耐受癌症治疗的能力和特殊人群（例如，老年人）。方法学的进步包括将生活质量数据与传统的治疗终点生存和反应相结合的新工具、方法和分析方法。这项工作也影响了癌症治疗试验的设计和累积。未来的方向：我们已经确定了生活质量研究的主要问题，将在所有疾病委员会解决。我们将通过主办一次旨在起草共识文件的国际会议来定义QOL终点的临床意义。其他研究的目标是使用个人问题作为临床干预的触发因素，并使用代理受访者来解决数据缺失的问题。我们将建立一个评估包，以确定体弱的老年癌症患者，以便修改治疗方法可以开发和社区肿瘤学实践中建立的联系计划，以解决个别患者的社会支持的赤字。我们还将探索使用补充疗法来管理疼痛，包括音乐和按摩。总结：NCCTG独特的社区实践为基础的结构，促进了高效，程序化，务实，务实的生活质量研究的发展。我们正处于一个关键时刻，因此目前的活动可以发展成为一个资金充足和功能强大的计划。

Our primary goal is to assess only relevant endpoints that have tangible outcomes for cancer patients and clinical practice. Over the previous grant period, QOL research has been organized into a programmatic approach following three themes: 1) assessing QOL endpoints efficiently within treatment trials; 2) designing trials targeted specifically to QOL endpoints; and 3) developing new QOL methodology. Cancer treatment delivery can be improved through direct intervention to impact QOL endpoints, improved QOL assessment methods, or interventions to ameliorate concomitant side effects. A barrier to the development of these research efforts has been the lack of dedicated resources. Preliminary Work: A guiding principle of our preliminary work can be summarized as "less is more". We demonstrated that a single item global QOL instrument can display greater sensitivity to change than a multi- tem tool aimed at the same construct. We use minimally sufficient sets of individual QOL items and a prior clinically significant effect sizes. Preliminary Work: A guiding principle of our preliminary work can be summarized as "less is more." We demonstrated that a single item global QOL instrument can display greater sensitivity to change than a multi- item tool aimed at the same construct. We use minimally sufficient sets of individual QOL items and a priori clinically significant effect sizes. Clinical trials work includes pilot studies that target QOL endpoints (such social support) which impact directly on the ability to receive and tolerate cancer treatments and special populations (e.g., the elderly). Methodological advances include new tools, approaches, and analytical methods for combining QOL data with the traditional treatment endpoints of survival and response. This work also impacts the design of and accrual to cancer treatment trials. Future Directions: We have identified major issues for QOL research which will be addressed across all disease committees. We will define clinical significance for QOL endpoints by hosting an international meeting with the purpose of drafting a consensus document. Other research targets the use of individual questions as clinical intervention triggers and the use of proxy respondents to address the issue of missing data. We will construct an assessment package to identify frail elderly cancer patients so that modified treatments can be developed and linkage programs established within the community oncology practices to address deficits in individual patient social support. We will also explore the use of complementary therapies for pain management, including music and massage. Summary: The unique community practice-based structure of NCCTG has fostered the development of efficient, programmatic, and pragmatic, and pragmatic QOL research. We are at a critical juncture whereupon the present activity can be grown into a fully funded and functional program.