QUALITY OF LIFE

我们的主要目标是只评估对癌症患者和临床实践具有切实结果的相关终点。在前一批赠款期间，QOL研究被组织成以下三个主题的方案方法：1)在治疗试验中有效地评估QOL终点；2)设计专门针对QOL终点的试验；以及3)开发新的QOL方法学。通过直接干预来影响生活质量终点，改进生活质量评估方法，或干预以减少伴随的副作用，可以改善癌症治疗的效果。阻碍这些研究工作发展的一个障碍是缺乏专门的资源。前期工作：我们前期工作的指导方针可以概括为“少就是多”。我们证明，与针对相同结构的多项工具相比，单项全球生活质量量表对变化的敏感度更高。我们使用最低限度的个体生活质量条目和先前临床显著效应大小的集合。前期工作：我们前期工作的指导方针可以概括为“少就是多”。我们证明，与针对同一结构的多项目工具相比，单项目全球生活质量量表对变化的敏感性更高。我们使用最低限度充足的个体生活质量项目和先验的临床显著效应大小。临床试验工作包括针对生活质量终点(如社会支持)的试点研究，这些终点直接影响接受和耐受癌症治疗的能力和特殊人群(如老年人)。方法学上的进步包括将生活质量数据与生存和反应的传统治疗终点相结合的新工具、新途径和新的分析方法。这项工作还影响癌症治疗试验的设计和收益。未来方向：我们已经确定了生活质量研究的主要问题，这些问题将在所有疾病委员会中得到解决。我们将通过主办一次旨在起草共识文件的国际会议，确定QOL终点的临床意义。其他研究的目标是使用个人问题作为临床干预的触发因素，并使用代理受访者来解决数据缺失的问题。我们将构建一套评估方案，以识别虚弱的老年癌症患者，以便开发改进的治疗方法，并在社区肿瘤学实践中建立联系计划，以解决个别患者社会支持方面的不足。我们还将探索使用辅助疗法来控制疼痛，包括音乐和按摩。摘要：NCCTG以社区实践为基础的独特结构促进了高效、规划、务实和务实的生活质量研究的发展。我们正处于一个关键时刻，目前的活动可以发展成为一个资金充足、功能齐全的方案。

Our primary goal is to assess only relevant endpoints that have tangible outcomes for cancer patients and clinical practice. Over the previous grant period, QOL research has been organized into a programmatic approach following three themes: 1) assessing QOL endpoints efficiently within treatment trials; 2) designing trials targeted specifically to QOL endpoints; and 3) developing new QOL methodology. Cancer treatment delivery can be improved through direct intervention to impact QOL endpoints, improved QOL assessment methods, or interventions to ameliorate concomitant side effects. A barrier to the development of these research efforts has been the lack of dedicated resources. Preliminary Work: A guiding principle of our preliminary work can be summarized as "less is more". We demonstrated that a single item global QOL instrument can display greater sensitivity to change than a multi- tem tool aimed at the same construct. We use minimally sufficient sets of individual QOL items and a prior clinically significant effect sizes. Preliminary Work: A guiding principle of our preliminary work can be summarized as "less is more." We demonstrated that a single item global QOL instrument can display greater sensitivity to change than a multi- item tool aimed at the same construct. We use minimally sufficient sets of individual QOL items and a priori clinically significant effect sizes. Clinical trials work includes pilot studies that target QOL endpoints (such social support) which impact directly on the ability to receive and tolerate cancer treatments and special populations (e.g., the elderly). Methodological advances include new tools, approaches, and analytical methods for combining QOL data with the traditional treatment endpoints of survival and response. This work also impacts the design of and accrual to cancer treatment trials. Future Directions: We have identified major issues for QOL research which will be addressed across all disease committees. We will define clinical significance for QOL endpoints by hosting an international meeting with the purpose of drafting a consensus document. Other research targets the use of individual questions as clinical intervention triggers and the use of proxy respondents to address the issue of missing data. We will construct an assessment package to identify frail elderly cancer patients so that modified treatments can be developed and linkage programs established within the community oncology practices to address deficits in individual patient social support. We will also explore the use of complementary therapies for pain management, including music and massage. Summary: The unique community practice-based structure of NCCTG has fostered the development of efficient, programmatic, and pragmatic, and pragmatic QOL research. We are at a critical juncture whereupon the present activity can be grown into a fully funded and functional program.