EASTERN COOPERATIVE ONCOLOGY GROUP

该提案的总体目标是扩大我们对癌症生物学的了解，利用这些知识为癌症患者设计新的治疗方法，在多机构前瞻性随机临床试验中测试这些新治疗方法，并通过在科学和医学期刊上发表同行评议出版物以及在科学和医学会议上发表报告来传播这些试验的结果。这些目标将通过以下方式实现：1)累积患者参加ECOG治疗试验和其他试验，并及时收集和报告这些试验的准确数据；2)在集团中发挥科学和行政领导作用；3)开展当地临床和实验室试点研究，这些研究结果可能作为更大规模ECOG研究的基础。4)利用ECOG对肿瘤学研究员和初级教师临床方法学的培训。我们在下一个资助期的具体目标是增加ECOG治疗和其他试验的累积，并担任几项完全或部分基于本机构试点数据的ECOG试验的研究主席，包括急性髓细胞白血病老年人血栓生成素的研究，慢性淋巴细胞白血病茶碱的研究，以及复发急性前髓细胞白血病三氧化二砷的研究。此外，还建议对结肠癌、宫颈癌和白血病进行实验室研究，利用ECOG研究组登记的新鲜和储存的患者样本。

The general aims of the proposal are to expand our knowledge of the biology of cancer, to utilize this knowledge to design new treatments for patients with cancer, to test such new treatments in multi-institutional prospective, randomized clinical trials, and to disseminate the results of such trials through peer review publication in scientific and medical journals, and by presentation at scientific and medical meetings. These aims will be accomplished by 1) accrual of patients to ECOG therapeutic and other trials and by collecting and reporting accurate data from those trials to ECOG in a timely fashion, 2) playing scientific and administrative leadership roles in the Group, 3) conducting local clinical and laboratory pilot studies the results of which may serve as bases for larger ECOG studies, and 4) by utilizing our ECOG participation in the training of oncology fellows and junior faculty in clinical methodology. Our specific aims in the next funding period are to increase accrual to ECOG therapeutic and other trials, and to serve as study chairs of several ECOG trials based entirely or in part on pilot data from this institution, including a study of thrombo-poietin in elderly adults with acute myeloid leukemia, a study of theophylline in chronic lymphocytic leukemia, and a study of arsenic trioxide in relapsed acute pro-myelocytic leukemia. In addition, laboratory investigations in colon cancer, cervical cancer and leukemia utilizing fresh and banked samples from patients enrolled on ECOG studies group wide are proposed.