SUPERFUND CHEMICALS IMPACT ON REPRODUCTION & DEVELOPMENT

建议设立的超级基金有害物质基础研究的主要主题 中心是阐明人体暴露和毒性的机制，以及 生态系统对特定的超级基金化学品的选择基于其 在生殖和发育影响方面的潜在意义。 该中心的主要目标如下：1)阐明 某些化学品的生殖和发育毒性 超级基金网站。重点将放在与细胞 信号和受体的相互作用参与脊椎动物的发育。2)至 促进在特定情况下获得的机械信息的传输 与人类和/或生态有关的脊椎动物模型(哺乳动物和鱼类) 健康。3)开发高灵敏、高效的生殖标记 和发育毒性，可以并入人类健康和 生态评估。4)阐明化学控制的机理。 选定化学品的运输和去向，以改进对 人类和生态系统暴露在超级基金站点的排放中。5)至 开发转基因斑马鱼和剑鱼(Fundulus)模型，将 有助于我们了解生殖和发育对 脊椎动物。这是研究核心的中心目标。6)建立 一种用于阐明人群中潜在暴露于以下疾病的策略 来自北卡罗来纳州和北卡罗来纳州特定超级基金地点的化学品 同时将这一信息传达给卫生专业人员， 社区领袖和公众。这是外展的中间派目标 核心。7)加强跨学科研究，以及研究生和研究生- 生物医学和环境科学方面的研究生培训。培训 CORE将建立在现有资源的基础上，如Duke的集成 毒理学计划，并将赞助特定的计划(研讨会、座谈会、 课程)专门与生物医学中的交叉受精进行比较 科学家、环境科学家、工程师和社会科学家。

The major theme of this proposed Superfund Hazardous Substances Basic Research Center is the elucidation of mechanisms of exposure and toxicity in humans and Ecosystems to particular Superfund chemicals selected based upon their potential significance with respect to reproductive and developmental effects. The major goals of the Center are as follows: 1) To elucidate mechanisms of reproductive and developmental toxicity of selected chemicals occurring at Superfund sites. Emphasis will be placed on mechanisms pertaining to cellular signaling and receptor interactions involved in vertebrate development. 2) To facilitate the transfer of mechanistic information obtained across particular vertebrate models (mammals and fishes) relevant to human and/or ecological health. 3) To develop highly sensitive and efficient markers for reproductive and developmental toxicities that can be incorporated into human health and ecological assessments. 4) To elucidate chemical mechanisms controlling the transport and fate of selected chemicals in order to improve predictions of human and ecosystem exposures to emissions from Superfund sites. 5) To develop transgenic zebrafish and killifish (Fundulus) models that will contribute to our understanding of reproductive and developmental impacts in vertebrates. This is the central goal of the Research Core. 6) To establish a strategy for elucidating potential exposures in human populations to chemicals emanating from selected Superfund sites in North Carolina and concomitantly communicating this information to health professionals, community leaders, and the public. This is the centrist goal of the Outreach Core. 7) To enhance interdisciplinary research, and graduate and post- graduate training in the biomedical and environmental sciences. The Training Core will build upon existing resources such as, as Duke's Integrated Toxicology Program and will sponsor specific programs (seminars, symposia, courses) Compared specifically to cross-fertilizations among biomedical scientists, environmental scientists and engineers and social scientists.