Core--DNA arrays

高密度DNA微阵列技术已经开始彻底改变描述生物现象的方式。这项技术的一个重要组成部分是它能够在正常或刺激条件下提供特定细胞类型的全球基因表达分子图谱。微阵列核心将使用标准的15,000个小鼠基因微阵列，以提供基于血细胞的炎症反应的详细基因图谱，并生成在我们的突变ES细胞克隆库中破坏的定制基因微阵列。当这些定制阵列被添加到全球15,000个基因阵列中时，将提供一种有效的手段来分析和优先处理新的转录本，以便进一步研究，并开发针对血液导向炎症的详细分子描述。

High density DNA microarray technology has begin to revolutionize the way biological phenomena are described. An important component of this technology is its ability to provide a global gene expression molecular profile of specific cell types under normal or stimulated conditions. The Microarray Core will use standard 15,000 mouse gene microarrays to provide a detailed gene profiling of blood cell-based inflammatory response as well as generate custom microarrays of genes disrupted in our libraries of mutant ES cell clones. These custom arrays when added to the global 15,000 gene arrays will provide an efficient means to analyze and prioritize novel transcripts for further studies and develop a detailed molecular description of blood-oriented inflammation.