Alcohol Involvement in Asian American Men and Women

描述：亚裔美国人作为一个整体，饮酒率较低， 在美国，酒精使用障碍比其他种族群体更多。研究 然而，在亚洲进行的研究表明，韩国人的 酒精滥用和依赖的终生流行率高于中国人。确实有 另有数据表明，这两个亚裔美国人亚群的差异很大 关于饮酒的模式、流行率和后果。整体而言 拟议研究项目的目标是确定相关变量 酗酒(饮酒和与酒精有关的问题) 21-25岁的华裔美国人和韩裔美国人使用 风险和保护因素方法。风险因素维度和保护因素维度 将重点评估与酒精使用有关的因素，并 在以前对亚洲人和其他种族群体的研究中与酒精有关的问题， 包括与酒精代谢有关的三个基因(ALDH2，ADH2， 和ADH3)，其他受遗传影响的因素(例如 酗酒)，以及心理社会变量。据推测，韩国人 美国人将比中国人拥有更少的保护因素和更多的风险因素 美国人。在参与者的一个子样本中，进行酒精和安慰剂挑战 将采用范式来衡量韩国人对酒精的反应水平 有没有酗酒父亲的美国人。据推测，那些 和一个酗酒的父亲会表现出对酒精不那么强烈的反应 而不是没有酗酒家族史的对照组。另外， 这项研究建议在样本内探索潜在的调解和 缓和易感因素和酗酒之间的关系。 具有明显不同模式的两个亚裔美国人群体的研究 酒精消费和酗酒提供了一个独特的机会来控制 某些特定遗传因素(酒精中的变异)的影响 新陈代谢基因)，同时寻找对饮酒的其他影响 行为以及这些因素可能如何与促进或防止饮酒有关 有问题。归根结底，更好地理解与 亚裔美国人的酒精行为将为 了解酒精滥用和依赖的原因，可能有助于 制定有效和文化敏感的预防和干预措施 程序。

DESCRIPTION: Asian Americans, as a whole, have lower rates of alcohol use and alcohol use disorders than other ethnic groups in the United States. Studies conducted in Asia, however, indicate that Koreans have a significantly higher lifetime prevalence of alcohol abuse and dependence than Chinese. There are also data to indicate that these two Asian American subgroups vary greatly with respect to patterns, prevalence and consequences of alcohol use. The overall objective of the proposed research project is to determine variables associated with alcohol involvement (alcohol consumption and alcohol-related problems) in 21-25 year old Chinese American and Korean American college students using a risk and protective factor approach. The risk and protective factor dimensions that will be evaluated will focus on factors related to alcohol use and alcohol-related problems in previous studies of Asians and other ethnic groups, including variation in three genes involved in alcohol metabolism (ALDH2, ADH2, and ADH3), other genetically influenced factors (e.g., family history of alcoholism), and psychosocial variables. It is hypothesized that Korean Americans will have fewer protective factors and more risk factors than Chinese Americans. In a subsample of participants, an alcohol and placebo challenge paradigm will be conducted to measure level of response to alcohol in Korean Americans with and without an alcoholic father. It is hypothesized that those with an alcoholic father will demonstrate less intense reactions to alcohol than matched controls without a family history of alcoholism. Additionally, this study proposes to explore, within the sample, potential mediating and moderating relationships between vulnerability factors and alcohol involvement. The study of two Asian American subgroups with significantly different patterns of alcohol consumption and alcoholism offers a unique opportunity to control the influence of some specific genetic factors (variation in the alcohol metabolism genes) while searching for additional influences on alcohol use behavior and how these factors may relate to promote or protect against alcohol problems. Ultimately, a better understanding of the factors associated with alcohol behavior in Asian Americans will contribute important information for understanding the causes of alcohol abuse and dependence and might aid in the development of efficacious and culturally sensitive prevention and intervention programs.