Alcohol Involvement in Asian American Men and Women

描述：亚裔美国人，作为一个整体，有较低的酒精使用率， 酒精使用障碍比美国其他种族群体。研究 然而，在亚洲进行的调查表明，韩国人的 酒精滥用和依赖的终生患病率高于中国人。有 也有数据表明，这两个亚裔美国人亚组的差异很大， 关于饮酒的模式、流行率和后果。整体 拟议研究项目的目标是确定相关变量 与酒精有关的问题（酒精消费和酒精相关问题） 21-25岁的华裔和韩裔美国大学生使用 风险和保护因素方法。风险和保护因素方面 将重点关注与酒精使用有关的因素， 酒精相关的问题在以前的研究亚洲人和其他种族群体， 包括参与酒精代谢的三种基因（ALDH 2，ADH 2， 和ADH 3），其他遗传影响因素（例如，家族史 酒精中毒）和心理社会变量。据推测，韩国 美国人将比中国人拥有更少的保护因素和更多的风险因素 美国人在参与者的子样本中，酒精和安慰剂挑战 范例将进行测量水平的反应，酒精在韩国 美国人有没有酗酒的父亲。据推测， 父亲酗酒的孩子对酒精的反应 与没有酗酒家族史的对照组相比，此外，本发明还 本研究建议在样本中探索潜在的中介作用， 脆弱性因素和酒精参与之间的调节关系。 两个具有显著不同模式的亚裔美国人亚组的研究 酒精消费和酒精中毒提供了一个独特的机会， 某些特定遗传因素（酒精含量的变化）的影响 代谢基因），同时寻找对酒精使用的其他影响 行为以及这些因素如何与促进或防止酒精有关 问题最终，更好地了解与 亚裔美国人的饮酒行为将为我们提供重要信息， 了解酒精滥用和依赖的原因，并可能有助于 制定有效和对文化敏感的预防和干预措施 程序.

DESCRIPTION: Asian Americans, as a whole, have lower rates of alcohol use and alcohol use disorders than other ethnic groups in the United States. Studies conducted in Asia, however, indicate that Koreans have a significantly higher lifetime prevalence of alcohol abuse and dependence than Chinese. There are also data to indicate that these two Asian American subgroups vary greatly with respect to patterns, prevalence and consequences of alcohol use. The overall objective of the proposed research project is to determine variables associated with alcohol involvement (alcohol consumption and alcohol-related problems) in 21-25 year old Chinese American and Korean American college students using a risk and protective factor approach. The risk and protective factor dimensions that will be evaluated will focus on factors related to alcohol use and alcohol-related problems in previous studies of Asians and other ethnic groups, including variation in three genes involved in alcohol metabolism (ALDH2, ADH2, and ADH3), other genetically influenced factors (e.g., family history of alcoholism), and psychosocial variables. It is hypothesized that Korean Americans will have fewer protective factors and more risk factors than Chinese Americans. In a subsample of participants, an alcohol and placebo challenge paradigm will be conducted to measure level of response to alcohol in Korean Americans with and without an alcoholic father. It is hypothesized that those with an alcoholic father will demonstrate less intense reactions to alcohol than matched controls without a family history of alcoholism. Additionally, this study proposes to explore, within the sample, potential mediating and moderating relationships between vulnerability factors and alcohol involvement. The study of two Asian American subgroups with significantly different patterns of alcohol consumption and alcoholism offers a unique opportunity to control the influence of some specific genetic factors (variation in the alcohol metabolism genes) while searching for additional influences on alcohol use behavior and how these factors may relate to promote or protect against alcohol problems. Ultimately, a better understanding of the factors associated with alcohol behavior in Asian Americans will contribute important information for understanding the causes of alcohol abuse and dependence and might aid in the development of efficacious and culturally sensitive prevention and intervention programs.