EQUIPMENT FOR MAXIMUM ISOLATION OVERFLOW HOUSING

最大程度隔离溢流外壳的设备

• 批准号: 6596633
• 负责人: Beverly J. Gnadt
• 金额: $ 37.26万
• 依托单位: STATE UNIVERSITY NEW YORK STONY BROOK
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-02-01 至 2005-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6596633
• 关键词: SCID mouse; animal care; animal colony; biomedical equipment purchase; building /facility design /renovation; genetically modified animals; laboratory mouse

DESCRIPTION (provided by applicant): The general objective of this project is to provide support and care for the use of transgenic, severely compromised immunodeficient (SClD), knockout, and specific pathogen free (SPF) mice at Stony Brook University (SBU). The Institution has both short-term and long-term goals to improve animal care and services for the faculty. This project will purchase equipment, and perform minor renovations for equipment installation, to upgrade maximum isolation overflow housing of SPF mice. Twenty-two basic and clinically applied research laboratories, that conduct research in gene identification, mapping, analysis and regulation; bacterial and viral receptor regulation; targeted gene therapy; infectious disease pathogenesis; oncology; cerebral amyloid angiopathy; vaccine development; and membrane transport, currently house animals in this overflow space. The project will purchase and renovate two existing animal rooms to install twenty-five ventilated racks. Four mobile, Class 100 animal transfer stations will be purchased and used within the animal rooms for cage servicing and experimental procedures. This equipment will improve the care of animals and address expanding research program needs by creating high density housing space for SPF mice, improving environmental conditions at the cage level to safeguard and preserve animal health, reducing occupational health risks for animal care and research personnel and decreasing labor costs.

描述（由申请人提供）： 该项目的一般目标是为使用Stony Brook University（SBU）的转基因，严重损害的免疫缺陷（SCLD），敲除和特定病原体（SPF）小鼠提供支持和护理。 该机构具有短期和长期目标，可以改善教师的动物护理和服务。 该项目将购买设备，并进行设备安装的少量翻新，以升级SPF小鼠的最大隔离溢出壳体。 22个基本和临床应用的研究实验室，这些研究实验室在基因识别，映射，分析和调节方面进行研究；细菌和病毒受体调节；靶向基因治疗；传染病发病机理；肿瘤学；脑淀粉样血管病；疫苗开发；和膜运输，目前在这个溢流空间中容纳动物。该项目将购买并翻新两个现有的动物室，以安装二十五个通风架。 将在动物室内购买和使用四个手机，100级动物转移站，用于笼子维修和实验程序。 该设备将通过为SPF小鼠创造高密度的住房空间，改善笼子水平的环境状况，以保护和保护动物健康，从而减少动物护理和研究人员的职业健康风险并降低劳动力成本，从而改善对动物的护理并满足不断扩大的研究计划需求。