RODENT BARRIER FACILITY EQUIPMENT

描述（由申请人提供）：本项目的总体目标是为乔治敦大学使用无病原体和转基因小鼠提供支持和护理。该机构有短期和长期目标，以改善动物护理和服务。这笔赠款将购买通风机架，进行小装修，并安装无线机架报警系统。15个基础和临床应用研究实验室，从事基因鉴定、绘图、 分析和调节;信号传导;细胞凋亡和肿瘤发生目前在啮齿动物屏障设施内的小鼠。 现有的1996年通风货架系统的设计、使用年限和缺乏安全功能，以及静态微型隔离器的使用，促使需要更换设备。节省空间的通风机架将最大限度地提高房屋密度，并支持研究扩展。空间效率的提高将允许去除静态微隔离笼，这将改善笼的环境条件和动物健康。具有直接排气能力的通风机架将通过减少房间过敏原含量来保护人员健康。无线报警系统将提醒工作人员设备/系统故障，并提供增强的动物住房安全。 这笔赠款将购买19180笼通风机架，空气调节阀和无线机架报警系统。该大学将继续通过购买机架笼设备和资助建设费用和A&E费用来支持动物资源。乔治敦大学啮齿动物屏障设施内的设备升级对于通过有效的空间利用最大限度地提高住房密度、保护啮齿动物群体和人员健康以及确保屏障设施小鼠的住房安全至关重要。

DESCRIPTION (provided by applicant): The general objective of this project is to provide support and care for the use of pathogen free and genetically modified mice at Georgetown University. The institution has both short and long term goals to improve animal care and services. This grant will purchase ventilated racks, perform minor renovations and install a wireless rack alarm system. Fifteen basic and clinically applied research laboratories who conduct research in gene identification, mapping, analysis and regulation; signaling; apoptosis and tumorigenesis currently house mice within the Rodent Barrier Facility. The design, age and lack of safety features on the existing 1996 ventilated racking system, and the use of static microisolater caging, drive the need for equipment replacement. Space efficient ventilated racks will maximize housing density and support research expansion. Increased space efficiency will allow removal of static microisolator cages which will improve environmental cage conditions and animal health. Ventilated racks with direct exhaust capability will safeguard personnel health by decreasing room allergen content. A wireless alarm system will alert staff of equipment/system malfunctions and provide enhanced animal housing safety. The grant will purchase nineteen, 180 cage ventilated racks, air regulator valves and a wireless rack alarm system. The University will continue to support the animal resource by purchasing rack caging equipment and funding construction costs and A&E fees. Equipment upgrade within the Rodent Barrier Facility at Georgetown University is essential to maximize housing density through efficient space utilization, safeguard rodent colony and personnel health and assure improved housing safety for barrier facility mice.