PURCHASE OF VENTILATED MOUSE CAGES

描述（由申请人提供）： 本动物资源改善项目拟为国家研究资源中心（NCRR）资助的两个建设项目购买通风鼠笼：转基因啮齿动物设施（GMRF）和程序和行为住房套房（PBHS）。 GMRF已获得了NCRR对方案设计和开发设计阶段的批准，并已提交了设计阶段III施工文件，计划于2002年7月1日开始施工（2002年11月完工）。 PBHS项目收到了授标意向通知，在等待资金和设计审查的情况下，应于2003年7月开始施工（2004年3月完工）。 该项目的短期目标是解决UCI教师正在进行的生物医学研究中小鼠住房的立即和严重短缺。 特别是，UCI研究人员使用转基因小鼠的数量在过去六年中平均每年增加28%。 GMRF的设计可容纳3，150个通风鼠笼; PBHS的设计可容纳1，926个鼠笼。 中央管理的大学实验室动物资源（ULAR）的长期目标是以与密集的实验室建设和教师招聘相匹配的速度发展动物舍;校园将在未来五年内投资500万至600万美元用于笼子。 连接到改进的动物资源是两个50,000平方米。英尺实验室大楼，斯普拉格和休伊特大厅，计划分别在2002年和2003年开放。 根据目前的使用情况，所要求的笼舍容量的大约一半将立即填满，其余的将在两年内因预计的快速增长而充分利用。 将为PBHS购买和安装1，926个笼，以配合PBHS的完成。 通风笼架被集成到GMRF和PBHS的设计方案中，以增加饲养密度，利用宝贵的屏障空间，最大限度地提高综合行为和程序研究，并帮助保护敏感和有价值的啮齿动物种群。

DESCRIPTION (provided by applicant): This animal resource improvement project proposes to purchase ventilated mouse cages for two National Center for Research Resources (NCRR)-funded construction projects: the Genetically Modified Rodent Facility (GMRF) and the Procedural and Behavioral Housing Suites (PBHS). The GMRF has received NCRR approval for both the schematic and development design phases, has submitted design Phase III construction documents, and is scheduled to begin construction on July 1, 2002 (completion November 2002). The PBHS project received a notice of intent to award and, pending funding and design review, should begin construction by July 2003 (completion March 2004). The short-term goal of this project is to address an immediate and serious shortfall in mouse housing for ongoing biomedical research by UCI faculty. In particular, the use of genetically modified mice by UCI researchers has increased by an average of 28 percent per year during the past six years. The GMRF is designed to accommodate 3,150 ventilated mouse cage and; the PBHS 1,926 mouse cages. The long-term goal of the centrally administered University Laboratory Animal Resources (ULAR) is to develop animal housing at a pace that matches intensive laboratory construction and faculty recruitment; the campus will invest $5 to $6 million in caging alone over the next five years. Connected to the improved animal resource are two 50,000 sq. ft. laboratory buildings, Sprague and Hewitt Hall, scheduled to open in 2002 and 2003, respectively. Based on current usage, approximately half of the requested caging capacity will be filled immediately, with the remainder fully utilized by rapid projected growth in two years. The 1,926 cages for the PBHS will be purchased and installed to coordinate with the completion of the PBHS. Ventilated cage racks were integrated into the design proposals for both GMRF and PBHS in order to increase housing density, leverage valuable barrier space, maximize integrated behavior and procedure research, and help protect sensitive and valuable rodent stocks.