Ventilated Mouse Cages for NIH Funded Construction Projects

描述（由申请人提供）： 该动物资源改善申请要求资金为加州大学欧文分校（UCI）的动物设施购买通风鼠笼和动物转移站，以支持PHS资助的研究人员。具体而言，所要求的资金将用于在现有吉莱斯皮动物园的10个饲养室中的36个单面通风笼架上进行圈养。位于吉莱斯皮神经科学研究设施的地下室，是最近最先进的实验室建设的中心，包括两座50，000 ASF实验室建筑（Sprague和休伊特霍尔），所要求的2，268个鼠笼，安装在一个1，515 ASF的综合拘留区，也直接毗邻两个NCRR资助的建设项目：已完成的转基因啮齿类动物设施（GMRF）和程序/行为/住房套房（PBHS），目前正在设计中。该项目的短期目标是解决UCI教师正在进行的PHS支持的生物医学研究中小鼠住房的立即和严重短缺。在过去的八年里，小鼠的使用以每年30%以上的平均速度增长，这在很大程度上是由于关键教师的招聘以及转基因的使用增加。在过去的三年里，校园已经投资了200万美元的通风笼，辅以一个成功的649,000美元的动物资源改善申请NCRR在2002年。校园计划在未来三年内投资至少300万美元的非NCRR资金用于校园设施的笼子和相关设备。中央管理的大学实验动物资源（ULAR）的长期目标是以与密集的实验室建设和教师招聘相匹配的速度开发高质量的动物舍。这支持了该机构的使命，创造了一个不断增长的能力，以支持公共卫生服务资助的生物医学研究人员。

DESCRIPTION (provided by applicant): This animal resource improvement application requests funds to purchase ventilated mouse cages and animal transfer stations for animal facilities at the University of California, Irvine (UCI), supporting PHS-funded researchers. Specifically, the requested funds would be invested in caging in 36 single-sided ventilated cage racks in 10 housing rooms in the existing Gillespie Vivarium. Located in the basement of Gillespie Neuroscience Research Facility and central to recent state-of-the-art laboratory construction, including two 50,000 ASF laboratory buildings (Sprague and Hewitt Hall), the requested 2,268 mouse cages, installed in a combined holding area of 1,515 ASF, also are directly adjacent to two NCRR-funded construction projects: the completed Genetically Modified Rodent Facility (GMRF) and the Procedural/Behavioral/Housing Suites (PBHS), currently in design. The short-term goal of this project is to address an immediate and serious shortfall in mouse housing for ongoing PHS-supported biomedical research by UCI faculty. Mouse use has increased at an average rate of 30+% per year over the last eight years, due in large part to key faculty recruitment combined with increasing use of transgenics. In the past three years the campus has invested $2 million in ventilated caging, supplemented by a successful $649,000 animal resource improvement application to NCRR in 2002. The campus plans to invest a minimum of $3 million in non-NCRR funds in caging and associated equipment for campus facilities in the next three years. The long-term goal of the centrally administered University Laboratory Animal Resources (ULAR) is to develop quality animal housing at a pace that matches intensive laboratory construction and faculty recruitment. This supports the agency's mission by creating a growing capacity to support PHS-funded biomedical researchers.