Sniff Magnitude Ratio as a Measure of Olfactory Acuity

嗅觉幅度比作为嗅觉敏锐度的衡量标准

• 批准号: 6907825
• 负责人: Robert C Gesteland
• 金额: $ 10.22万
• 依托单位: COMPUSNIFF, LLC
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-08-01 至 2005-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6907825
• 关键词: anosmia; biomedical equipment; biomedical equipment development; clinical research; diagnosis design /evaluation; human subject; measurement; neuropsychological tests; odors; olfactions; olfactory disorder; psychometrics; sensory disorder diagnosis

DESCRIPTION (provided by applicant): Smell loss is a health and safety problem for millions of Americans. Assessment of smell function is not routinely performed because a rapid, inexpensive and robust test of olfaction is not available. Our SBTR Phase I grant demonstrated the feasibility of a new test of olfactory function, the sniff magnitude test. The test performed well in reliability and validity studies with adults as compared to standard tests, and proved to be superior to the UPSIT in tests with children. Because the sniff test is based on reflex-like reduction of sniffing to a malodorous stimulus, it is hypothesized that it will have advantages over standard tests that require substantial cognitive, memory and language skills. This SBIR Phase II application aims to enhance the sniff magnitude test by (1) improving the odor delivery and sniff measurement equipment and protocol, (2) reducing the cost of the test device, (3) demonstrate the utility of the test in the clinic, and (4) providing robust demonstrations of the advantages of the test with populations who have proved difficult or time consuming to evaluate with existing olfactory acuity tests.

描述(申请人提供)：气味丧失是一个健康和安全问题 对数百万美国人来说。嗅觉功能的评估并不是常规的 因为快速、廉价和可靠的嗅觉测试不是 可用。我们的SBTR第一阶段拨款证明了一项新的测试的可行性 嗅觉功能、嗅觉大小测试。这项测试在#年表现良好。 与标准测试相比的成人信度和效度研究，以及 在儿童测试中被证明优于UPSIT。因为嗅觉 测试的基础是像反射一样将嗅觉减少为恶臭刺激，它 假设它将比标准测试更有优势 具有丰富的认知、记忆和语言技能。此SBIR第二阶段 应用程序旨在通过(1)改善气味来增强嗅觉强度测试 交付和嗅探测量设备和协议，(2)降低成本 该测试装置，(3)证明该测试在临床上的实用性，以及(4) 有力地展示了该测试在人群中的优势 谁被证明很难或耗时地用现有的嗅觉进行评估 视力测试。