Automated Sequence Variation Analysis Software

自动序列变异分析软件

• 批准号: 6626041
• 负责人: CHARLES L MAGNESS
• 金额: $ 24.83万
• 依托单位: ILLUMIGEN BIOSCIENCES, INC.
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-04-01 至 2004-10-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6626041
• 关键词: Barretts esophagus; CpG islands; DNA methylation; Internet; automated data processing; clinical research; computer assisted sequence analysis; computer program /software; computer system design /evaluation; data management; gene mutation; genetic polymorphism; human tissue; messenger RNA; molecular biology information system; nucleic acid sequence; phenotype

DESCRIPTION (provided by applicant): Phase II development of an automated DNA sequence variation analysis software package is proposed. The software analyzes diploid DNA sequencing and mixed methylation analysis samples from phenotypically stratified patient groups. The software package detects essentially all mutations of any type, and then classifies and scores them. The goals of this Phase II are to improve upon the successful Phase I implementation and complete the originally proposed development plan. This includes automated interpretation of mutations and methylation state and association of detected mutations with a phenotypic group. PROPOSED COMMERCIAL APPLICATION: NOT AVAILABLE

描述（由申请人提供）：自动化DNA的II期开发 序列变异分析软件包。该软件分析 二倍体DNA测序和混合甲基化分析样本， 表型分层的患者组。软件包检测到 基本上所有类型的突变，然后对它们进行分类和评分。的 第二阶段的目标是在第一阶段成功的基础上加以改进 并完成原计划的发展。这 包括突变和甲基化状态的自动解释， 检测到的突变与表型组的关联。 拟议商业应用：不可用