Neurobiology and Cognitive Impairment Of The Elderly

描述（由申请人提供）：该计划项目名为 “长者轻度认知障碍的神经生物学”汇集了一个 来自芝加哥和其他地方的基础科学家和临床科学家 高校该项目将设在拉什长老会-圣卢克的 芝加哥的医疗中心。该项目由一个行政 具有临床/组织分布组件和统计和数据的核心 管理核心。此外，以下四个研究项目完成 该项目：1）MCI中Tau、A β、Synuclein和氧化/硝化损伤 (John Trojanowski，宾夕法尼亚大学，项目负责人）; 2）年龄相关 老年人的神经病理学和轻度认知障碍（Dennis Dickson， 马约诊所，项目负责人）; 3）胆碱能基底前脑神经营养 老年人的Abstract和轻度认知障碍（Elliot Mufson， 项目负责人）;以及 老年人（史蒂芬DeKosky，匹兹堡大学，项目负责人）。每个 核心将支持所有这些研究项目。此外，这些项目 将从NIA资助的Rush ADC获得临床数据和组织样本 宗教秩序研究核心和神经病理学核心的所有项目。的 PPG产生的这些数据的结果将为神经病学提供新的启示 轻度认知障碍和向AD过渡的老年人， 为痴呆症发作的治疗策略提供了新的见解。

DESCRIPTION (provided by applicant): The Program Project entitled "Neurobiology of Mild Cognitive Impairment in the Elderly" brings together a number of basic scientists and clinical scientists from Chicago and outside universities. The project will be based at Rush Presbyterian-St. Luke's Medical Center in Chicago. The Program Project consists of an Administrative Core with a Clinical/Tissue Distribution component and a Statistics and Data Management Core. In addition, the following four research projects complete the program: 1) Tau, A beta, Synuclein and Nitrative/Oxidative Damage in MCI (John Trojanowski, University of Pennsylvania, project leader); 2) Age Related Neuropathology and Mild Cognitive Impairment in the Elderly (Dennis Dickson, Mayo Clinic, project leader); 3) Cholinergic Basal Forebrain Neurotrophic Abnormalities and Mild Cognitive Impairment in the Elderly (Elliot Mufson, Project Leader); and Synaptic Abnormalities and Mild Cognitive Impairment in the Elderly (Steven DeKosky, University of Pittsburgh, project leader). Each core will support all of these research projects. Moreover, these projects will receive clinical data and tissue samples from the NIA funded Rush ADC Religious Orders Study Core and the Neuropathology Core for all projects. The results of this data produced by the PPG will shed new light on the neurology of elderly people with mild cognitive impairment and the transition to AD and provide novel insights into treatment strategies for the onset of dementia.