Archiving the Charleston Heart Study

查尔斯顿心脏研究存档

• 批准号: 6533526
• 负责人: Paul J Nietert
• 金额: $ 7.3万
• 依托单位: MEDICAL UNIVERSITY OF SOUTH CAROLINA
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-08-01 至 2004-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6533526
• 关键词: African American; aging; archives; behavior; cardiovascular disorder risk; caucasian American; clinical research; coronary disorder; epidemiology; functional ability; gender difference; human data; human middle age (35-64); human old age (65+); information dissemination; longitudinal human study; racial /ethnic difference; social psychology; socioeconomics; vital statistics

DESCRIPTION (provided by applicant): Archiving the Charleston Heart Study (CHS) data collected over a 41-year period (1960-2000) will facilitate important research efforts directed toward understanding the natural progression of aging in a community based cohort. Enhancement of current scientific knowledge related to the socioeconomic and behavioral characteristics of an aging biracial community cohort may be possible through secondary data analyses of this unique data set. The CHS began enrolling a random selection of community residents in 1960 who were then 35 years of age and older - including men and women, black and white. The primary hypothesis of the original study was to investigate racial differences in the manifestation and risk factors for coronary disease. Over the ensuing 40+ years, a variety of outcome measurements were incorporated into the reexamination of the participants, including psychosocial, behavioral, aging and functional measures. The aims of this application are to document and preserve the Charleston Heart Study for future research efforts, to update the vital status of the cohort, and to establish mechanisms for distributing the data and documentation to researchers in a manner that will facilitate its use, and provide user support and technical services. Archiving this longitudinal data for its future scientific use will ensure the necessary foundation for subsequent studies to expand scientific knowledge of the risk factors, correlates and consequences of aging, while simultaneously allowing for exploration of racial disparity in the manifestation of putative risk factors and outcomes.

描述(由申请人提供)：将41年(1960-2000)期间收集的查尔斯顿心脏研究(CHS)数据存档，将有助于重要的研究工作，旨在了解社区队列中衰老的自然进程。通过对这一独特的数据集进行二次数据分析，可以增强与老龄化的混血群体队列的社会经济和行为特征有关的当前科学知识。CHS从1960年开始随机选择当时年龄在35岁及以上的社区居民-包括男性和女性，黑人和白人。最初研究的主要假设是调查冠心病的表现和危险因素的种族差异。在接下来的40多年里，在对参与者的复查中纳入了各种结果测量，包括心理社会、行为、衰老和功能测量。该应用程序的目的是为未来的研究工作记录和保存查尔斯顿心脏研究，更新队列的重要状态，并建立机制，以便于使用的方式将数据和文件分发给研究人员，并提供用户支持和技术服务。将这些纵向数据存档，以供未来的科学使用，将确保为后续研究奠定必要的基础，以扩大关于老龄化的风险因素、相关性和后果的科学知识，同时允许探索假定的风险因素和结果表现中的种族差异。

项目成果

Lipoprotein(a) concentration and the risk of coronary heart disease, stroke, and nonvascular mortality.

• DOI: 10.1001/jama.2009.1063
• 发表时间: 2009-07-22
• 期刊: JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
• 影响因子: 120.7
• 作者: Erqou, Sebhat;Kaptoge, Stephen;Perry, Philip L.;Di Angelantonio, Emanuele;Thompson, Alexander;White, Ian R.;Marcovina, Santica M.;Collins, Rory;Thompson, Simon G.;Danesh, John
• 通讯作者: Danesh, John

Diabetes mellitus, fasting blood glucose concentration, and risk of vascular disease: a collaborative meta-analysis of 102 prospective studies.

• DOI: 10.1016/s0140-6736(10)60484-9
• 发表时间: 2010-06-26
• 期刊: LANCET
• 影响因子: 168.9
• 作者: Sarwar, N.;Gao, P.;Seshasai, S. R. Kondapally;Gobin, R.;Kaptoge, S.;Di Angelantonio, E.;Ingelsson, E.;Lawlor, D. A.;Selvin, E.;Stampfer, M.;Stehouwer, C. D. A.;Lewington, S.;Pennells, L.;Thompson, A.;Sattar, N.;White, I. R.;Ray, K. K.;Danesh, J.;Tipping, R. W.;Ford, C. E.;Pressel, S. L.;Folsom, A. R.;Chambless, L. E.;Wagenknecht, L. E.;Panagiotakos, D. B.;Pitsavos, C.;Chrysohoou, C.;Stefanadis, C.;Knuiman, M.;Whincup, P. H.;Wannamethee, S. G.;Morris, R. W.;Kiechl, S.;Willeit, J.;Oberhollenzer, F.;Mayr, A.;Wald, N.;Ebrahim, S.;Yarnell, J. W.;Gallacher, J.;Casiglia, E.;Tikhonoff, V.;Nietert, P. J.;Sutherland, S. E.;Bachman, D. L.;Keil, J. E.;de Boer, I. H.;Kizer, J. R.;Mukamal, K. J.;Tybjaerg-Hansen, A.;Nordestgaard, B. G.;Benn, M.;Frikke-Schmidt, R.;Giampaoli, S.;Palmieri, L.;Panico, S.;Vanuzzo, D.;Pilotto, L.;de la Camara, A. Gomez;Rubio, M. A.;Simons, L.;McCallum, J.;Friedlander, Y.;Fowkes, F. G. R.;Lee, A. J.;Taylor, J.;Guralnik, J. M.;Phillips, C. L.;Wallace, R.;Guralnik, J. M.;Phillips, C. L.;Blazer, D. G.;Guralnik, J. M.;Phillips, C. L.;Phillips, C. L.;Guralnik, J. M.;Khaw, K. T.;Brenner, H.;Raum, E.;Mueller, H.;Rothenbacher, D.;Jansson, J. H.;Wennberg, P.;Nissinen, A.;Donfrancesco, C.;Giampaoli, S.;Salomaa, V.;Harald, K.;Jousilahti, P.;Vartiainen, E.;Woodward, M.;D'Agostino, R. B.;Vasan, R. S.;Fox, C. S.;Pencina, M. J.;Bladbjerg, E.;Jorgensen, T.;Moller, L.;Jespersen, J.;Dankner, R.;Chetrit, A.;Lubin, F.;Wilhelmsen, L.;Eriksson, H.;Svardsudd, K.;Welin, L.;Rosengren, A.;Wilhelmsen, L.;Lappas, G.;Eriksson, H.;Bjorkelund, C.;Lissner, L.;Bengtsson, C.;Cremer, P.;Nagel, D.;Strandberg, T. E.;Salomaa, V.;Tilvis, R. S.;Miettinen, T. A.;Tilvis, R. S.;Strandberg, T. E.;Kiyohara, Y.;Arima, H.;Doi, Y.;Ninomiya, T.;Rodriguez, B.;Dekker, J. M.;Nijpels, G.;Stehouwer, C. D. A.;Rimm, E.;Pai, J. K.;Sato, S.;Iso, H.;Kitamura, A.;Noda, H.;Goldbourt, U.;Nyyssonen, K.;Tuomainen, T. P.;Salonen, J. T.;Deeg, D.;Poppelaars, J. L.;Meade, T. W.;Cooper, J. A.;Hedblad, B.;Berglund, G.;Engstrom, G.;Verschuren, W. M. M.;Blokstra, A.;Cushman, M.;Folsom, A. R.;Psaty, B. M.;Shea, S.;Doring, A.;Koenig, W.;Meisinger, C.;Mraz, W.;Verschuren, W. M. M.;Blokstra, A.;Bueno-de-Mesquita, H. Bas;Wilhelmsen, L.;Rosengren, A.;Lappas, G.;Fletcher, A.;Kuller, L. H.;Grandits, G.;Selmer, R.;Tverdal, A.;Nystad, W.;Gillum, R.;Mussolino, M.;Rimm, E.;Hankinson, S.;Manson, J. E.;Pai, J. K.;Salomaa, V.;Harald, K.;Jousilahti, P.;Vartiainen, E.;Cooper, J. A.;Bauer, K. A.;Davidson, K. W.;Kirkland, S.;Shaffer, J.;Korin, M. R.;Kitamura, A.;Sato, S.;Iso, H.;Holme, I.;Selmer, R.;Tverdal, A.;Nystad, W.;Ducimetiere, P.;Jouven, X.;Bakker, S. J. L.;Gansevoort, R. T.;Hillege, H. L.;Crespo, C. J.;Palmieri, M. R. Garcia;Amouyel, P.;Arveiler, D.;Evans, A.;Ferrieres, J.;Schulte, H.;Assmann, G.;Westendorp, R. G.;Buckley, B. M.;Packard, C. J.;Sattar, N.;Cantin, B.;Lamarche, B.;Despres, J. P.;Dagenais, G. R.;Barrett-Connor, E.;Wingard, D. L.;Bettencourt, R.;Gudnason, V.;Aspelund, T.;Sigurdsson, G.;Thorsson, B.;Trevisan, M.;Witteman, J.;Kardys, I.;Breteler, M.;Hofman, A.;Tunstall-Pedoe, H.;Tavendale, R.;Lowe, G. D. O.;Woodward, M.;Howard, B. V.;Zhang, Y.;Best, L.;Umans, J.;Ben-Shlomo, Y.;Davey-Smith, G.;Onat, A.;Hergenc, G.;Can, G.;Njolstad, I.;Mathiesen, E. B.;Lochen, M. L.;Wilsgaard, T.;Zethelius, B.;Riserus, U.;Berne, C.;Ingelsson, E.;Gaziano, J. M.;Stampfer, M.;Ridker, P.;Gaziano, J. M.;Ridker, P.;Ulmer, H.;Diem, G.;Concin, H.;Tosetto, A.;Rodeghiero, F.;Manson, J. E.;Tinker, L.;Liu, S.;Howard, B. V.;Marmot, I. M.;Clarke, R.;Collins, R.;Fletcher, A.;Brunner, E.;Shipley, M.;Ridker, P.;Buring, J.;Shepherd, J.;Cobbe, S. M.;Ford, I.;Robertson, M.;Ibanez, A. Marin;Feskens, E. J. M.;Kromhout, D.;Walker, M.;Watson, S.;Alexander, M.;Di Angelantonio, E.;Erqou, S.;Gao, P.;Gobin, R.;Haycock, P.;Kaptoge, S.;Seshasai, S. R. Kondapally;Lewington, S.;Pennells, L.;Perry, P. L.;Ray, K. K.;Sarwar, N.;Thompson, A.;Thompson, S. G.;Walker, M.;Watson, S.;White, I. R.;Wood, A. M.;Wormser, D.;Danesh, J.
• 通讯作者: Danesh, J.