Role of Fatigue in Rheumatic Diseases

描述(申请人提供)：疲劳是风湿性疾病的常见症状，也是纤维肌痛(FM)和其他相关疾病、类风湿性关节炎(RA)、骨关节炎(OA)和系统性红斑狼疮(SLE)患者身体功能障碍的最强预测指标之一。然而，在风湿性疾病中，关于疲劳的原因和机制的研究很少。缺乏关于疲劳在风湿病中的作用的科学证据，直接影响到卫生保健专业人员评估疲劳的存在、严重程度和轨迹，以及评估疲劳与这些疾病的其他症状的关系以便提供适当的治疗建议的能力。疲劳是伴随慢性病而出现的最常见、但最不为人所知且尚未缓解的症状之一。拟议讲习班的主要目标是建立一个关于风湿病疲劳的最新信息的知识库，并将其与癌症、艾滋病毒/艾滋病、中风和多发性硬化症疲劳的研究所获得的知识状况进行比较。这一过程将有助于确定有关疲劳在风湿病中的作用的知识差距。未来风湿性疾病疲劳研究的方向将被建议纳入在其他躯体疾病中已被证明成功的研究方法。为了实现这些目标，一批来自神经科学、生理学、免疫学和精神病学/心理学、临床实践等不同科学领域的著名疲劳和睡眠研究人员以及公共利益团体的代表将被邀请参加2004年3月18日和19日在新泽西州弗洛勒姆公园的杜勒斯汉密尔顿公园会议中心举行的研讨会。演讲一般涉及疲劳的定义、概念化和评估，将继续对FM、RA、OA、SLE、癌症、艾滋病毒/艾滋病、中风和多发性硬化症的疲劳研究进行最先进的概述，并将在分组讨论中集中讨论。将在会议结束时编写一份总结这次研讨会成果的立场声明，并通过发表在同行评议的期刊上散发。拟议研讨会的协作和互动性质将确保所产生的建议将对科学界产生广泛影响，并将在对风湿病感兴趣的科学家和临床医生之间产生协作和互动的研究。

DESCRIPTION (provided by applicant): Fatigue is a common complaint in rheumatic disorders and is one of the strongest predictors of physical dysfunction in patients with Fibromyalgia (FM) and other related disorders, rheumatoid arthritis (RA), osteoarthritis (OA), and systemic lupus erythematosus (SLE). However, research addressing the causes and mechanisms of fatigue is rare in rheumatic illnesses. The lack of scientific evidence focusing on the role of fatigue in rheumatic illness directly impacts on the ability of health care professionals to assess the presence, severity and trajectory of fatigue and to evaluate the relationship of fatigue with other symptoms of these disorders in order to provide appropriate treatment recommendations. Fatigue is one of the most commonly reported, yet least understood and unrelieved symptoms accompanying chronic illnesses. The primary objective of the proposed workshop is to establish a knowledge base of current information on fatigue in rheumatic illness that will be compared with the state of knowledge gained from studies of fatigue in cancer, HIV/AIDS, stroke, and MS. This process will serve to identify knowledge gaps concerning the role of fatigue in rheumatic illness. Directions for future fatigue research in rheumatic illness will be suggested incorporating research methodologies that have proven successful in other somatic disorders. To achieve these objectives, a group of renowned fatigue and sleep researchers drawn from a variety of scientific areas including neuroscience, physiology, immunology, and psychiatry/psychology, clinical practice, as well as representatives of public interest groups will be invited to attend a workshop to be held on March 18 and 19, 2004 at the Dolce Hamilton Park Conference Center in Florham Park, NJ. Presentations addressing definition, conceptualization, and assessment of fatigue in general will proceed state-of-the-art overviews of fatigue research in FM, RA, OA, SLE, cancer, HIV/AIDS, stroke, and MS, and will be followed by concentrated discussions in break-out groups. A position statement summarizing the results from this workshop will be produced at the conclusion of the meeting and disseminated via publication in a peer-reviewed journal. The collaborative and interactive nature of the proposed workshop will ensure that the recommendations generated will have a broad impact on the scientific community, and will generate collaborative, interactive research amongst scientists and clinicians with an interest in rheumatic illnesses.