RESEARCH ON SCOPE & CAUSES OF STILLBIRTH IN THE US

范围研究

• 批准号: 6727251
• 负责人: MARSHALL W CARPENTER
• 金额: $ 38.96万
• 依托单位: WOMEN AND INFANTS HOSPITAL-RHODE ISLAND
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-09-26 至 2008-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6727251
• 关键词: clinical research; cooperative study; disease /disorder etiology; embryo /fetus death; epidemiology; human subject; human tissue; postmortem; preeclampsia; pregnancy disorder; pregnancy immunology; premature labor; prenatal growth disorder

DESCRIPTION (provided by applicant): Women and Infants Hospital (WIH) has served as the regional resource for tertiary obstetrical and neonatal care for decades for all the communities in Rhode Island and those of Bristol County, MA. This compact, contiguous area, well defined by state and county boundaries, contains a stable, but racially and ethnically heterogeneous population, producing 20,000 total births and more than 100 stillbirths, annually. Births at WlH represent over 70% of those that occur state-wide and nearly half of those in the region, and are highly representative of those from the region's population. As a specialty hospital, WIH has maintained an active outreach program to the region's nurses, physicians and hospitals for the past 26 years. This active engagement has included educational support in the areas of neonatology, obstetrics and pathology. WlH has also maintained an active collaboration with the Rhode Island Department of Health (DOH) in many initiatives regarding reproductive health. This proposal is made with the enthusiastic support of the Departments of Health of both states and the chiefs of obstetrics and pathology and administration of all the region's 14 hospitals with obstetrical services. The Department of Pathology at WIH has maintained an extensive relational database of its autopsy and placental examinations and relevant clinical information since 1975. Paraffin-imbedded standard tissues sections from these examinations also provide for examination of time-trends of stillbirths occurring in a stable population over the past two decades. The Department has sustained an 80% autopsy rate at WIH and stimulated the rising rate among the other region's hospitals, now at 30%. A rising proportion of the stillbirths occurring at other hospitals are being referred to WlH for autopsy and placental examination. Consequently, because of the leadership role of WIH in RI and Bristol County, MA, the close proximity of the 14 hospitals serving its population, and the collegial relations among health care providers, this region is well adapted to provide the resources for a population-based study of the causes of stillbirth in a stable, diverse population-based sample of 20,000 annual births.

描述（由申请人提供）：妇女和婴儿医院（WIH）几十年来一直是罗得岛和马萨诸塞州布里斯托县所有社区的三级产科和新生儿护理的区域资源。这一紧凑、毗连的地区，由州和县边界明确界定，人口稳定，但种族和民族多样，每年共生产20 000名新生儿和100多名死胎。出生在WlH代表超过70%的那些发生在全州和近一半的那些在该地区，是高度代表性的那些从该地区的人口。 作为一家专科医院，WIH在过去的26年里一直积极地与该地区的护士、医生和医院开展外联活动。这种积极参与包括在生殖医学、产科和病理学领域提供教育支助。妇女健康协会还与罗得岛卫生部在许多有关生殖健康的倡议中保持积极合作。这一建议得到了两个州卫生部以及该地区所有14家提供产科服务的医院的产科和病理科主任和行政部门的热情支持。 自1975年以来，WIH的病理学系一直保持着一个广泛的尸检和胎盘检查以及相关临床信息的相关数据库。这些检查的石蜡包埋标准组织切片也可用于检查过去二十年稳定人群中死产的时间趋势。该部在WIH维持了80%的尸检率，并刺激了其他地区医院的尸检率上升，目前为30%。在其他医院发生的死产中，越来越多的死产被转介到WlH进行尸检和胎盘检查。因此，由于WIH在RI和布里斯托县的领导作用，MA，14家为其人口服务的医院的接近，以及卫生保健提供者之间的合议关系，该地区非常适合提供资源，以人口为基础的研究死产的原因，在一个稳定的，多样化的人口为基础的样本，每年20,000名新生儿。