NICHD Maternal Fetal Medicine Units Network

描述（由申请人提供）：妇女和婴儿医院（WIH）和布朗大学医学院的妇产科在其第一个供资周期期间实现了对母胎医学单位网络的高水平参与。WIH MFM单位在登记患者数量方面排名网络单位的前一半，在可识别患者比例和数据质量方面排名前三。妇女研究所对MFMU网络表现出了高度的部门和机构承诺，提供了大量的空间和基础设施支持，并维持了一些协议中出现的收入短缺，以优化该股对网络的功能。该司在过去和现在由NIH资助的多机构观察试验中也表现良好（非整倍体风险的FastER胎儿超声研究（已完成），高血压和不良妊娠结局和死胎合作研究网络研究，仍在进行中。MFM单位在一个地点（WIH）运作，每年生产超过9 500个新生儿，是全国最大的生产基地之一。WIH产科患者的种族/民族分布、经济状况和医疗特征反映了罗得岛的情况，因为WIH占该州出生人数的71%以上。WIH患者的代表性有助于网络研究结果的普遍性。WIH患者表现出预期的基于人群的临床特征。WIH患者的种族多样性为66%的白色，9%的黑人和4%的亚洲人。在14%的WIH患者中发现了西班牙裔种族身份。在50%以上的WIH分娩中发现了生物风险因素，如糖尿病（8.9%）、早产（5.8%）、高血压疾病（11.6%）、哮喘（4.5%）和多胎妊娠（2.4%）。此外，社会风险因素，如未婚（38%），未满18岁（3%）和出生时没有保险（10%），使人们有机会解决基于社会差距和生物学的假设。WIH MFM股很强。该司由六名MFM医生组成，其中三名接受过流行病学研究培训。该科有一个积极性高、效果好的研究护士小组，他们表现出高度的适应能力。妇女健康研究所也是新生儿研究网络的一个单位。这些特点使布朗/妇女和婴儿股成为更新供资的理想候选人。

DESCRIPTION (provided by applicant): Women and Infants Hospital (WIH) and the Ob/Gyn Department at Brown University Medical School have achieved a high level of participation in the Maternal-Fetal Medicine Units Network during its first funding cycle. The WIH MFM Unit, has ranked in the top half of Network Units in number of enlisted patients and in the top third with respect to enlistedielligible patient ratio and data quality. WIH has demonstrated a high degree of departmental and institutional commitment to the MFMU Network, providing significant space and infrastructure support and sustaining revenue shortfalls that have occurred in some protocols in order to optimize this Unit's functionality for the Network. The Division has also performed well in past and present NIH-funded multi-institutional observational trails (the FaSTER fetal sonography study of aneuploidy risk (completed), the Hyperglycemia and Adverse Pregnancy Outcome and the Stillbirth Cooperative Research Network studies, still ongoing. The MFM Unit operates on one site (WIH), productive of over 9500 annual births, one of the Nation's largest. The racial/ethnic distribution, economic status, and medical characteristics among WIH obstetrical patients mirror those of Rhode Island, insofar as WIH accounts for more than 71% of State births. The representative nature of WIH patients facilitates the generalizability of Network study findings. The WIH patients demonstrate expected population-based clinical characteristics. WIH patients are racially diverse with 66% white, 9% black, and 4% Asian. Hispanic ethnic identity is found in 14% of WIH patients. Biological risk factors such as diabetes (8.9%), premature birth (5.8%), hypertensive disorders (11.6%), asthma (4.5%) and multifetal pregnancy (2.4%) are found in over 50% of WIH deliveries. Moreover, social risk factors such as being unmarried (38%), under 18 years old (3%) and uninsured (10%) at time of birth admission allow opportunity to address hypotheses based on social disparity as well as biology. The WIH MFM Unit is strong. The Division is composed of six MFM physicians, three of whom have epidemiologic research training. The Division has a highly motivated and effect group of research nurses who have demonstrated a high degree of adaptability. WIH is also home to a Unit of the Neonatal Research Network. These attributes make the Brown/Women & Infants Unit a desirable candidate for funding renewal.