NICHD Maternal Fetal Medicine Units Network

描述（由申请人提供）：布朗大学医学院的妇幼医院和妇产科在母胎医学单位网络的第一个资助周期内实现了高水平的参与。与MFM单位，已排在网络单位的上半部分在登记的患者数量和在前三分之一在登记的合格患者比例和数据质量。人道主义事务部对MFMU网络表现出高度的部门和机构承诺，提供了大量的空间和基础设施支持，并维持在某些协议中出现的收入短缺，以便优化该股对该网络的功能。该部门在过去和现在由美国国立卫生研究院资助的多机构观察试验中也表现良好（非整倍体风险的快速胎儿超声研究（已完成），高血糖和不良妊娠结局以及死产合作研究网络研究，仍在进行中）。MFM单位在一个站点（WIH）上运作，每年生产9500多名新生儿，是全国最大的站点之一。怀孕孕妇的种族/民族分布、经济状况和医疗特点与罗德岛州的情况相似，因为怀孕孕妇占该州新生儿的71%以上。随着患者的代表性，有利于网络研究结果的普遍性。withh患者表现出预期的基于人群的临床特征。患者种族多样，白人占66%，黑人占9%，亚洲人占4%。在14%的艾滋病患者中发现西班牙裔身份。50%以上的分娩伴有糖尿病（8.9%）、早产（5.8%）、高血压疾病（11.6%）、哮喘（4.5%）和多胎妊娠（2.4%）等生物学风险因素。此外，诸如在出生时未婚（38%）、未满18岁（3%）和未投保（10%）等社会风险因素为解决基于社会差异和生物学的假设提供了机会。与MFM单位是强大的。该司由6名MFM医生组成，其中3人受过流行病学研究培训。该科拥有一支高度积极和有效的研究护士团队，他们表现出高度的适应能力。卫生组织也是新生儿研究网络的一个单位的所在地。这些特点使布朗/妇女和婴儿部门成为资金更新的理想候选人。

DESCRIPTION (provided by applicant): Women and Infants Hospital (WIH) and the Ob/Gyn Department at Brown University Medical School have achieved a high level of participation in the Maternal-Fetal Medicine Units Network during its first funding cycle. The WIH MFM Unit, has ranked in the top half of Network Units in number of enlisted patients and in the top third with respect to enlistedielligible patient ratio and data quality. WIH has demonstrated a high degree of departmental and institutional commitment to the MFMU Network, providing significant space and infrastructure support and sustaining revenue shortfalls that have occurred in some protocols in order to optimize this Unit's functionality for the Network. The Division has also performed well in past and present NIH-funded multi-institutional observational trails (the FaSTER fetal sonography study of aneuploidy risk (completed), the Hyperglycemia and Adverse Pregnancy Outcome and the Stillbirth Cooperative Research Network studies, still ongoing. The MFM Unit operates on one site (WIH), productive of over 9500 annual births, one of the Nation's largest. The racial/ethnic distribution, economic status, and medical characteristics among WIH obstetrical patients mirror those of Rhode Island, insofar as WIH accounts for more than 71% of State births. The representative nature of WIH patients facilitates the generalizability of Network study findings. The WIH patients demonstrate expected population-based clinical characteristics. WIH patients are racially diverse with 66% white, 9% black, and 4% Asian. Hispanic ethnic identity is found in 14% of WIH patients. Biological risk factors such as diabetes (8.9%), premature birth (5.8%), hypertensive disorders (11.6%), asthma (4.5%) and multifetal pregnancy (2.4%) are found in over 50% of WIH deliveries. Moreover, social risk factors such as being unmarried (38%), under 18 years old (3%) and uninsured (10%) at time of birth admission allow opportunity to address hypotheses based on social disparity as well as biology. The WIH MFM Unit is strong. The Division is composed of six MFM physicians, three of whom have epidemiologic research training. The Division has a highly motivated and effect group of research nurses who have demonstrated a high degree of adaptability. WIH is also home to a Unit of the Neonatal Research Network. These attributes make the Brown/Women & Infants Unit a desirable candidate for funding renewal.