The Stereoselective Synthesis of Heterocycles Through Cation-Triggered Annulation

该项目属于EPSRC合成有机化学的研究领域。从简单易得的原料中立体选择性地合成高度官能化的饱和杂环的方法是非常可取的，因为它们在医药和农化工业中的价值以及它们在天然产品中的广泛存在。例如，在FDA列出的小分子药物中，6元饱和氮杂环是第三种最常见的环系，吡咯烷、(四氢)-呋喃和-吡喃也位居前12名。不仅起始材料必须容易获得，而且工艺需要廉价、高效和原子经济。在Donohoe基团中已经建立了一种这样的方法，利用六氟异丙醇(HFIP)的独特性质作为极性和氢键溶剂，使烯烃能够进行立体选择性官能化。最近，它被应用于通过高烯丙醇与活化醇反应生成具有高立体选择性的新的C-C和C-O键来合成含氧杂环。使用亚化学计量比的钛(OIPR)4和HFIP作为溶剂，在正式的内触发环化过程中，通过富电子的烯烃捕获亲醇产物产生碳正离子，生成水作为唯一的化学计量副产物。目前正在进行含氮杂环的合成工作，有可能将这一方法扩展到其他杂环的合成。我们的目标是改进目前的氢胺化方法，这些方法虽然有很好的先例，但往往依赖于昂贵的金属催化剂的使用，并且缺乏产品的非对映选择性和官能化。一旦实现了这一点，将进一步使产品多样化，以增加其作为医药和农用化学品工业基石的用途。此外，我们希望通过使用不对称金属催化，使该过程具有对映选择性，从而使该方法更适用于天然产物的合成。最后，我们希望通过合成其他在配位和药物化学中具有广泛用途的复杂杂环来探索这一过程的局限性。环中含有两个杂原子的其他杂环将被评估，从而得到另一类高度官能化的分子。总体而言，开发这一方法的目的是在不影响成本或操作简单性的情况下，为当前获取饱和杂环的方法提供更有效和更有选择性的替代方法。此外，我们希望所获得的复杂分子将被证明是药物和农业化学的有用构建块，为“类铅”化合物提供3D模板。

This project falls within the EPSRC Synthetic Organic Chemistry research area.Methods for the stereoselective synthesis of highly functionalized saturated heterocycles from simple and readily available starting materials are highly desirable due to their value in medicinal and agro- chemical industries along with their widespread presence in natural products. For example, piperidines, the 6-membered saturated nitrogen heterocycles are the third most prevalent ring system in small molecule drugs listed by the FDA, with pyrrolidines, (tetrahydro) -furans and -pyrans also featuring in the top twelve. Not only do the starting materials have to be easily accessible but the process needs to be cheap, efficient and atom economical. One such method has been established in the Donohoe group, using the unique properties of hexafluoroisopropanol (HFIP) as a polar and hydrogen bonding solvent to enable the stereoselective functionalization of alkenes. Recently, this has been applied to the synthesis of oxygen heterocycles through reaction of a homoallylic alcohol with an activated alcohol to generate a new C-C and C-O bond with high stereoselectivity. The use of sub-stoichiometric amounts of Ti(OiPr)4 and HFIP as the solvent generates a carbocation from the alcohol electrophile which is trapped by an electron rich olefin in a formal endo-trig cyclisation, generating water as the only stoichiometric by-product. There is potential to extend this methodology to the synthesis of other heterocycles with work currently underway on the synthesis of nitrogen containing heterocycles. We aim to improve on the current hydroamination methods, which although well precedented, often rely on the use of expensive metal catalysts and suffer from a lack of diastereoselectivity and functionalization of the product. Once this has been achieved, further diversification of the products will be undertaken in order to increase their utility as building blocks in the medicinal and agro- chemical industries. In addition, we hope to make the process enantioselective, through the use of asymmetric metal catalysis, this would in turn make the methodology more applicable to the synthesis of natural products. Finally, we hope to probe the limits of this process through the synthesis of other complex heterocycles which have a wide array of uses in coordination and medicinal chemistry. Other heterocycles containing two heteroatoms in the ring will be evaluated giving an additional class of highly functionalized molecules. Overall, the development of this methodology aims to offer a more efficient and selective alternative to the current methods for accessing saturated heterocycles without compromising cost or operational simplicity. In addition, we hope that the complex molecules accessed will prove to be useful building blocks for medicinal and agro- chemistry giving 3D Templates for "Lead-Like" compounds.