Multicenter Network of Neonatal Intensive Care Units

新生儿重症监护室多中心网络

• 批准号: 6615685
• 负责人: DALE L. PHELPS
• 金额: $ 35.55万
• 依托单位: UNIVERSITY OF ROCHESTER
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-05-01 至 2006-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6615685
• 关键词: clinical trials; cooperative study; disease /disorder proneness /risk; health care facility information system; human subject; human therapy evaluation; low birth weight infant human; mother /infant health care; neonatal intensive care; newborn human (0-6 weeks); obstetrics; patient oriented research; pediatric nursing; pediatrics; perinatal; pregnancy disorder; premature infant human; prenatal care; prenatal diagnosis

DESCRIPTION: (Provided by Applicant) The University of Rochester proposes to participate in the NICHD Collaborative Neonatal Research Network This Network was formed 15 years ago to develop reliable scientific evidence for best clinical practice. By combining the populations of many intensive units, sufficient sample sizes of adequate diversity are enrolled in a reasonable time frame. The Network also collects prospective observational data for pilot projects, calculating sample sizes, and identification of key issues for future studies. Efforts are coordinated with a parallel Maternal-Fetal Medicine Network, and success and productivity relies on the creativity, design skills, experience and dedicated work of the center principal investigators that make up the Steering Committees, and the dedicated research staff that conduct the trials and collect the data. Dale L. Phelps brings a wealth of personal experience in designing and conducting neonatal multi-center randomized trials. In addition, the other 10 academic faculty have also been conducting multi-center randomized trials and basic research for 18+ years, while caring for the 1200 NICU admissions annually. They work closely with the Maternal-Fetal Medicine Division as the Regional Perinatal Center with established maternal transport of known high risk pregnancies, ensuring a stable population for recruitment. The NICU Follow-up Program evaluates all NICU graduates meeting high risk criteria (-20%), plus all infants in research protocols. In addition, all NICU graduates (high risk or not) are tracked via mailed annual questionnaires to families and physicians through age 5 years. Over 93% follow up has been accomplished for enrolled research subjects in follow up studies to date. The Children?s Hospital at Strong Perinatal Center at the University of Rochester has a large diverse neonatal population, experienced investigative faculty, and an outstanding Medical Research Institute. This center will be an outstanding participating Network Center. Dale Phelps as the PI, will be a dedicated participant and contributor on the Steering Committee and working subcommittees.

描述：（由申请人提供）罗切斯特大学建议 NICHD新生儿协作研究网络（NICHD Collaborative Neonatal Research Network） 成立于15年前，旨在为最好的 临床实践通过结合许多密集单位的人口， 在合理的范围内招募足够的样本量和足够的多样性。 时间框架。该网络还为试点项目收集前瞻性观测数据， 项目，计算样本量，并确定关键问题， 未来的研究。努力与平行的母胎协调 医学网络，成功和生产力依赖于创造力， 中心负责人的设计技能、经验和敬业精神 组成指导委员会的调查人员，以及专门的研究 进行试验和收集数据的工作人员。 戴尔湖菲尔普斯带来了丰富的个人经验，在设计和 进行新生儿多中心随机试验。此外，其他10个 学术人员也一直在进行多中心随机试验， 18年以上的基础研究，同时照顾1200名新生儿重症监护室入院患者 每年。他们与母胎医学部密切合作， 地区围产期中心，已建立产妇运输已知高 怀孕风险，确保招募的稳定人口。新生儿重症监护室 后续计划评估所有符合高风险标准的NICU毕业生（-20%）， 加上所有研究方案中的婴儿此外，所有NICU毕业生 (high风险与否）通过每年向家庭邮寄问卷进行跟踪 5岁以上的医生。已完成93%以上的随访 对于迄今为止随访研究中入组的研究受试者。 孩子们？在斯特朗围产期中心的大学s医院 罗切斯特有一个庞大的多样化的新生儿人口，经验丰富的调查 学院，以及一个杰出的医学研究所。这个中心将是一个 优秀的参与网络中心。戴尔菲尔普斯作为PI，将是一个 指导委员会的专门参与者和贡献者， 小组委员会。