MULTICENTER NETWORK OF NEONATAL INTENSIVE CARE UNITS

新生儿重症监护病房的多中心网络

• 批准号: 6740882
• 负责人: DALE L. PHELPS
• 金额: $ 47.43万
• 依托单位: UNIVERSITY OF ROCHESTER
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-05-01 至 2006-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6740882
• 关键词: clinical trials; cooperative study; disease /disorder proneness /risk; health care facility information system; human subject; human therapy evaluation; low birth weight infant human; mother /infant health care; neonatal intensive care; newborn human (0-6 weeks); obstetrics; patient oriented research; pediatric nursing; pediatrics; perinatal; pregnancy disorder; premature infant human; prenatal care; prenatal diagnosis

DESCRIPTION: (Provided by Applicant) The University of Rochester proposes to participate in the NICHD Collaborative Neonatal Research Network This Network was formed 15 years ago to develop reliable scientific evidence for best clinical practice. By combining the populations of many intensive units, sufficient sample sizes of adequate diversity are enrolled in a reasonable time frame. The Network also collects prospective observational data for pilot projects, calculating sample sizes, and identification of key issues for future studies. Efforts are coordinated with a parallel Maternal-Fetal Medicine Network, and success and productivity relies on the creativity, design skills, experience and dedicated work of the center principal investigators that make up the Steering Committees, and the dedicated research staff that conduct the trials and collect the data. Dale L. Phelps brings a wealth of personal experience in designing and conducting neonatal multi-center randomized trials. In addition, the other 10 academic faculty have also been conducting multi-center randomized trials and basic research for 18+ years, while caring for the 1200 NICU admissions annually. They work closely with the Maternal-Fetal Medicine Division as the Regional Perinatal Center with established maternal transport of known high risk pregnancies, ensuring a stable population for recruitment. The NICU Follow-up Program evaluates all NICU graduates meeting high risk criteria (-20%), plus all infants in research protocols. In addition, all NICU graduates (high risk or not) are tracked via mailed annual questionnaires to families and physicians through age 5 years. Over 93% follow up has been accomplished for enrolled research subjects in follow up studies to date. The Children?s Hospital at Strong Perinatal Center at the University of Rochester has a large diverse neonatal population, experienced investigative faculty, and an outstanding Medical Research Institute. This center will be an outstanding participating Network Center. Dale Phelps as the PI, will be a dedicated participant and contributor on the Steering Committee and working subcommittees.

描述：(申请人提供)罗切斯特大学建议 参加NICHD协作新生儿研究网这一网络 成立于15年前，旨在为BEST提供可靠的科学证据 临床实践。通过将许多密集单元的种群组合在一起， 足够的样本大小和足够的多样性被纳入一个合理的 时间框架。该网络还为飞行员收集预期的观测数据 项目、计算样本量和确定关键问题 未来的研究。努力与平行的母婴协调 医疗网络，而成功和生产力依赖于创造力， 中心校长的设计技巧、经验和敬业精神 组成指导委员会的调查人员，以及专门的研究 进行试验和收集数据的工作人员。 戴尔·L·菲尔普斯带来了丰富的个人设计经验和 进行新生儿多中心随机试验。此外，其他10个 学术人员也一直在进行多中心随机试验和 基础研究18年以上，同时照顾1200名NICU入院患者 每年一次。他们与母婴医学司密切合作，作为 地区围产期中心已建立的母婴转运已知的高 有怀孕风险，确保有稳定的招募人口。NICU 后续计划评估所有符合高风险标准的NICU毕业生(-20%)， 加上研究方案中的所有婴儿。此外，所有NICU毕业生 (高危或非高危)通过邮寄给家庭的年度调查问卷进行跟踪 以及5岁以下的医生。已完成93%以上的跟踪 对于登记在册的研究对象，目前正在进行后续研究。 儿童？北京大学斯特朗围产期中心S医院 罗切斯特有一个庞大的多样化的新生儿人口，经验丰富的调查 教职员工和一所杰出的医学研究所。这个中心将是一个 优秀参与网络中心。戴尔·菲尔普斯作为PI，将成为 指导委员会和工作的热心参与者和贡献者 小组委员会。