MULTICENTER NETWORK OF MATERNAL-FETAL MEDICINE UNITS

母胎医学单位的多中心网络

• 批准号: 6608157
• 负责人: John M Thorp
• 金额: $ 87.69万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-04-18 至 2006-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6608157
• 关键词: clinical trials; cooperative study; disease /disorder proneness /risk; embryo /fetus disorder; female; human pregnant subject; human subject; human therapy evaluation; mother /infant health care; neonatal intensive care; newborn human (0-6 weeks); obstetrics; patient oriented research; pediatrics; perinatal; pregnancy; pregnancy disorder; premature infant human; prenatal care; prenatal diagnosis; women's health

Research focused on challenges in clinical obstetrics at the University of North Carolina is sophisticated and wide-ranging with outstanding investigators addressing fundamental topics in maternal-fetal care. The scope of research activities ranges from leadership and participation in national, multi-site randomized trials, to continued accrual of a cohort of more 3,000 prenatal patients, and to novel translation research bringing benchwork to the bedside. The topics of this research are equally broad exploring clinical interventions such as septostomy for twin-twin transfusion, the epidemiology of preterm birth, and the relationship between oral infection, inflammatory response and birth outcomes. Based in a tradition of excellence in patient care, teaching, and academic dedication, the Division of Maternal-Fetal Medicine has consistently sought opportunities to collaborate in state-of-the-art research. Furthermore, during the last five years, the Division has specifically built capability to be an effective and productive partner in endeavors such as the Cooperative Multicenter Maternal-Fetal Medicine Units Network. The UNC Division of MFM and Wake Area Health Education Center, Division of Obstetrics and Gynecology, have a ten-year record of successful research partnership that provides the foundation for this application. Each partner has comprehensive clinical care facilities, 24-hr research pharmacy services, Level 3 neonatal care units, data collection systems, and strengths in integrating complex research protocols into clinical care. Our sites have 4,800 births each year, overwhelmingly indigent patients, of whom 72% receive Medicaid or have no insurance. Thirty-three to 41 % are high risk by virtue of maternal comorbidities, fetal anomalies, pregnancy complications, or preterm birth risk profile, including multiple gestations. Minority women are well-represented with near balance between African Americans (35%), Whites (33%), and Hispanics (29%). Given our dedication to quality research, the depth of institutional commitment, strength of our investigators, and breadth of resources, we are prepared to serve the Network well.

北卡罗来纳州大学的研究重点是临床产科的挑战，是复杂和广泛的，杰出的研究人员解决了母婴护理的基本主题。研究活动的范围包括领导和参与国家多地点随机试验，继续招募3，000多名产前患者，以及将台式工作带到床边的新型翻译研究。这项研究的主题同样广泛，探索临床干预措施，如双胞胎输血的中隔造口术，早产的流行病学，以及口腔感染，炎症反应和出生结局之间的关系。基于卓越的病人护理，教学和学术奉献的传统，母胎医学部一直在寻求机会，在国家的最先进的研究合作。此外，在过去五年中，该司专门建立了能力，成为合作性多中心母婴医疗单位网络等努力的有效和富有成效的合作伙伴。MFM和威克地区健康教育中心，妇产科分部，有十年的成功研究伙伴关系，为这一应用提供了基础。每个合作伙伴都拥有全面的临床护理设施，24小时研究药房服务，3级新生儿护理单位，数据收集系统，以及将复杂的研究方案整合到临床护理中的优势。我们的网站每年有4,800名新生儿，绝大多数是贫困患者，其中72%接受医疗补助或没有保险。33%至41%的孕妇由于母体合并症、胎儿畸形、妊娠并发症或早产风险特征（包括多胎妊娠）而具有高风险。少数族裔妇女的比例很高，非洲裔美国人（35%）、白人（33%）和西班牙裔美国人（29%）的比例接近平衡。鉴于我们致力于高质量的研究，机构承诺的深度，我们的调查人员的力量和资源的广度，我们准备好为网络服务。