MULTICENTER NETWORK OF MATERNAL-FETAL MEDICINE UNITS

北卡罗来纳大学专注于产科临床挑战的研究是复杂和广泛的，杰出的研究人员解决了母婴护理的基本主题。研究活动的范围从领导和参与国家多地点随机试验，到继续积累3000多名产前患者的队列，以及将钳工带到床边的新颖翻译研究。这项研究的主题同样广泛，探索临床干预措施，如用于双胞胎输血的隔膜造口术，早产的流行病学，以及口腔感染、炎症反应和出生结局之间的关系。基于在病人护理、教学和学术奉献方面的卓越传统，母胎医学部一直在寻找在最先进的研究方面进行合作的机会。此外，在过去五年中，该司特别建立了能力，使其成为合作多中心孕产妇-胎儿医疗股网络等努力中的有效和富有成效的合作伙伴。MFM的北卡罗来纳大学分部和维克地区健康教育中心，妇产科分部，有十年的成功研究合作记录，为这一申请提供了基础。每个合作伙伴都拥有全面的临床护理设施、24小时研究药房服务、3级新生儿护理单元、数据收集系统以及将复杂的研究方案整合到临床护理中的优势。我们的网站每年有4800名新生儿出生，其中绝大多数是贫困患者，其中72%接受医疗补助或没有保险。33%至41%的孕妇因母体合并症、胎儿畸形、妊娠并发症或早产风险特征(包括多胎妊娠)而处于高危状态。少数族裔女性的比例很高，非洲裔美国人(35%)、白人(33%)和西班牙裔美国人(29%)几乎平衡。鉴于我们对高质量研究的奉献精神、机构承诺的深度、我们研究人员的实力和资源的广度，我们准备好为网络提供良好的服务。

Research focused on challenges in clinical obstetrics at the University of North Carolina is sophisticated and wide-ranging with outstanding investigators addressing fundamental topics in maternal-fetal care. The scope of research activities ranges from leadership and participation in national, multi-site randomized trials, to continued accrual of a cohort of more 3,000 prenatal patients, and to novel translation research bringing benchwork to the bedside. The topics of this research are equally broad exploring clinical interventions such as septostomy for twin-twin transfusion, the epidemiology of preterm birth, and the relationship between oral infection, inflammatory response and birth outcomes. Based in a tradition of excellence in patient care, teaching, and academic dedication, the Division of Maternal-Fetal Medicine has consistently sought opportunities to collaborate in state-of-the-art research. Furthermore, during the last five years, the Division has specifically built capability to be an effective and productive partner in endeavors such as the Cooperative Multicenter Maternal-Fetal Medicine Units Network. The UNC Division of MFM and Wake Area Health Education Center, Division of Obstetrics and Gynecology, have a ten-year record of successful research partnership that provides the foundation for this application. Each partner has comprehensive clinical care facilities, 24-hr research pharmacy services, Level 3 neonatal care units, data collection systems, and strengths in integrating complex research protocols into clinical care. Our sites have 4,800 births each year, overwhelmingly indigent patients, of whom 72% receive Medicaid or have no insurance. Thirty-three to 41 % are high risk by virtue of maternal comorbidities, fetal anomalies, pregnancy complications, or preterm birth risk profile, including multiple gestations. Minority women are well-represented with near balance between African Americans (35%), Whites (33%), and Hispanics (29%). Given our dedication to quality research, the depth of institutional commitment, strength of our investigators, and breadth of resources, we are prepared to serve the Network well.