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MULTICENTER NETWORK OF MATERNAL-FETAL MEDICINE UNITS

MULTICENTER NETWORK OF MATERNAL-FETAL MEDICINE UNITS
母胎医学单位的多中心网络
批准号:
6608156
负责人:
BRIAN M. MERCER
金额:
$84.01万
依托单位国家:
美国
项目类别:
财政年份:
2001
资助国家:
美国
项目状态:
已结题
起止时间:
2001-04-01 至 2006-03-31

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中文摘要
翻译
描述(由申请人提供):本申请的目标是 证明#年部门的母胎医学股 凯斯西储大学(CWRU)生殖生物学有资格 参加NICHD母婴医学股网络(MFMU网络), 这种参与将加强MFMU网络并提供领导 在开发和开展合作研究方面, 个人MFM单元以及新生儿研究人员的合作。建议数 研究人员有临床研究的背景,包括多中心 需要新生儿和长期随访的研究和研究。该单位 拥有广泛的临床和研究兴趣,包括:预测和 预防早产、围产期感染、引产、产妇 碳水化合物代谢/糖尿病,怀孕期间的能量消耗, 子痫前期的病理生理与预防、产前诊断及胎儿 评估、胎盘功能和营养。而CWRU之前没有 参加了MFMU网络,它已经证明了以前和 持续参与合作和NIH资助的多中心研究。 首席调查员有10年的成功合作历史 在MFMU网络中担任德克萨斯大学孟菲斯分校的候补首席调查员。 在此期间,他在发展和开展 MFMU网络试验,以及在网络中?管理结构。在这 建议,CWRU提供其两个小学教学的参与 附属机构、MetroHealth医疗中心和大学医院(包括 彩虹婴幼儿?S医院)。这两家医院的合并提供了一个 招聘大量女性,并可集中成本/时间 从不同的人群中高效地招募选定的对象。CWRU?S 美国国立卫生研究院资助的普通临床研究中心有一个既定的记录 成功的围产期研究。CWRU-GCRC?S值通过以下方式提高 位于MetroHealth医学中心和大学医院的单元。 这两个单元都可支持MFMU网络试验,可以执行辅助 在他们的核心实验室中进行研究,并可以作为 多中心研究。彩虹婴幼儿?S医院参与 NICHD新生儿研究网络自成立以来,提供了特别的 长期跟踪研究方面的专业知识。它提供了一座潜在的桥梁, MFMU和NICU网络之间的协作以及后续行动 MFMU网络研究。建议的CWRU MFMU单位提供经验丰富的 临床医生和研究人员,大量不同的患者群体,以及 具备开展合作临床研究的能力。建议数 MFM和新生儿学研究人员已经证明了合作的能力 跨越地理、医院和部门边界,包括外部和 在NICHD MFMU和NICU网络内部。CWRU现有的基础设施 为增强和经济高效的研究提供了潜力,以及 有能力设计和支持辅助研究。调查人员认为 他们能够成功地为MFMU网络做出贡献,并且他们提供 潜在的领导力,因为网络在协作、 21世纪的纵向研究。
英文摘要
DESCRIPTION (provided by applicant): The goal of this application is to demonstrate that the Maternal-Fetal Medicine Unit in the Department of Reproductive Biology at Case Western Reserve University (CWRU) is qualified to participate in the NICHD Maternal-Fetal Medicine Units Network (MFMU Network), and that participation will strengthen the MFMU Network and provide leadership in the development and conduct of collaborative research between the individual MFM Units as well as with neonatal researchers. The proposed investigators have backgrounds in clinical research, including multicenter studies and studies requiring neonatal and long term follow-up. The Unit possesses diverse clinical and research interests including: prediction and prevention of preterm birth, perinatal infection, labor induction, maternal carbohydrate metabolism/diabetes, energy expenditure in pregnancy, pathophysiology and prevention of preeclampsia, prenatal diagnosis and fetal assessment, placental function, and nutrition. While CWRU has not previously participated in the MFMU Network, it has demonstrated evidence of prior and ongoing participation in collaborative and NIH funded multicenter research. The Principal Investigator has a 10-year history of successful collaboration within the MFMU Network as the alternate Principal Investigator for UT-Memphis. During that time he played a role in the development and conduct of MFMU Network trials, and in the Networks? administrative structure. In this proposal, CWRU offers the participation of its two primary teaching affiliates, MetroHealth Medical Center and University Hospitals (including Rainbow Babies & Children?s Hospitals). Inclusion of both hospitals offers a large number of women for recruitment, and could allow focused cost/time efficient recruitment of selected subjects from a diverse population. CWRU?s NIH-funded General Clinical Research Center has an established record of successful perinatal research. The CWRU-GCRC?s value is enhanced by having Units located at both MetroHealth Medical Center and at University Hospitals. Both Units are available to support MFMU Network trials, can perform ancillary studies in their core laboratories, and could act as a Central Lab for multicenter studies. Rainbow Babies & Children?s Hospital has participated in the NICHD Neonatal Research Network since its inception, and offers special research expertise in long term follow-up. It offers a potential bridge for collaboration between the MFMU and NICU Networks in addition to follow-up for MFMU Network studies. The proposed CWRU MFMU Unit offers experienced clinicians and researchers, a large diverse patient population, as well as a demonstrated ability to conduct collaborative clinical research. The proposed MFM and Neonatology researchers have demonstrated the ability to collaborate across geographic, Hospital and Departmental boundaries, both outside and inside the NICHD MFMU and NICU Networks. The existing infrastructure at CWRU offers the potential for enhanced and cost-effective research as well as the ability to design and support ancillary studies. The investigators believe that they can successfully contribute to the MFMU Network and that they offer potential leadership as the Network expands its efforts in collaborative, longitudinal studies in the 21st Century.
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Pregnancy as a Window to Future Cardiovascular Health
  • 批准号:
    8841408
  • 项目类别:
  • 资助金额:
    $4.82万
  • 财政年份:
    2013
  • 负责人:
    BRIAN M. MERCER
  • 依托单位:
Pregnancy as a Window to Future Cardiovascular Health
  • 批准号:
    8723285
  • 项目类别:
  • 资助金额:
    $4.44万
  • 财政年份:
    2013
  • 负责人:
    BRIAN M. MERCER
  • 依托单位:
Pregnancy as a Window to Future Cardiovascular Health
  • 批准号:
    8576073
  • 项目类别:
  • 资助金额:
    $4.51万
  • 财政年份:
    2013
  • 负责人:
    BRIAN M. MERCER
  • 依托单位:
Adverse Outcomes in Nulliparous Pregnancies: The Ohio Collaborative
  • 批准号:
    8204810
  • 项目类别:
  • 资助金额:
    $21.61万
  • 财政年份:
    2010
  • 负责人:
    BRIAN M. MERCER
  • 依托单位:
海外基金