Epidemiology of Osteoporotic Fractures in the Very Frail Elderly: Risk factors, Quality of Life and Mortality

非常虚弱老年人骨质疏松性骨折的流行病学：危险因素、生活质量和死亡率

• 批准号: nhmrc : 211278
• 负责人: Prof Ian Cameron
• 金额: $ 22.71万
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2002
• 资助国家: 澳大利亚
• 起止时间: 2002-01-01 至 2004-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/epidemiology-osteoporotic-fractures-life-mortality/96466
• 关键词: Epidemiology; Osteoporotic; Fractures; Very; Frail

Osteoporosis, a disease characterised by skeletal fragility, is a major public health problem. The direct costs alone of treating osteoporotic fractures have been estimated at more than $800 million in Australia. Hip fractures are the most costly to treat and are due to a fall or injury in over 90% of cases. The frail elderly are at particular risk of osteoporotic fractures but little is known about risk fractures in this 'at risk' group or the effect of fracture on quality of life. This study is examining risk factors for fractures in the frail and institutionalised older person by asessment of quantitative bone ultrasound, falls risk, vitamin D status and other biochemical markers of bone in an attempt to identify predictors that can be modified to reduce fractures, improve quality of life and reduce mortality due to osteoporotic fractures.

骨质疏松症是一种以骨骼脆弱为特征的疾病，是一个主要的公共卫生问题。据估计，在澳大利亚，仅治疗骨质疏松性骨折的直接费用就超过8亿美元。髋部骨折是治疗成本最高的，超过90%的病例是由于跌倒或受伤造成的。体弱的老年人是在特别危险的骨折，但很少有人知道风险骨折在这个“风险”组或骨折对生活质量的影响。本研究通过评估定量骨超声、福尔斯风险、维生素D状态和其他骨生化标志物来检查虚弱和机构化老年人骨折的风险因素，试图确定可修改的预测因子，以减少骨折，改善生活质量并降低因骨质疏松性骨折导致的死亡率。