Epidemiology of Osteoporotic Fractures in the Very Frail Elderly: Risk factors, Quality of Life and Mortality

非常虚弱老年人骨质疏松性骨折的流行病学：危险因素、生活质量和死亡率

• 批准号: nhmrc : 211278
• 负责人: Prof Ian Cameron
• 金额: $ 22.71万
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2002
• 资助国家: 澳大利亚
• 起止时间: 2002-01-01 至 2004-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/epidemiology-osteoporotic-fractures-life-mortality/96466
• 关键词: Epidemiology; Osteoporotic; Fractures; Very; Frail

Osteoporosis, a disease characterised by skeletal fragility, is a major public health problem. The direct costs alone of treating osteoporotic fractures have been estimated at more than $800 million in Australia. Hip fractures are the most costly to treat and are due to a fall or injury in over 90% of cases. The frail elderly are at particular risk of osteoporotic fractures but little is known about risk fractures in this 'at risk' group or the effect of fracture on quality of life. This study is examining risk factors for fractures in the frail and institutionalised older person by asessment of quantitative bone ultrasound, falls risk, vitamin D status and other biochemical markers of bone in an attempt to identify predictors that can be modified to reduce fractures, improve quality of life and reduce mortality due to osteoporotic fractures.

骨质疏松症是一种以骨骼脆弱性为特征的疾病，是一个主要的公共卫生问题。澳大利亚，仅处理骨质疏松性骨折的直接成本估计超过8亿美元。髋部骨折是治疗最昂贵的，这是由于超过90％的病例跌倒或受伤。脆弱的老年人特别有骨质疏松性骨折的风险，但对此“处于风险”组的风险骨折或裂缝对生活质量的影响知之甚少。这项研究正在检查脆弱和机构化的老年人骨折的危险因素，方法是通过定量骨超声，下降风险，维生素D状态和其他骨骼的其他生化标志物来识别可以修改的预测因子，以减少裂缝，改善裂缝，改善生活质量并降低造成骨质骨膜的死亡率。