NEURAL BASIS FOR RECOVERY OF FUNCTION AFTER STROKE

描述：该项目的长期目标是检查神经系统 脑卒中后运动功能恢复的基础及 康复训练方案对神经生理和行为结果的影响。 这些研究将使用神经生理学和行为训练技术， 成年灵长类动物检查初级运动功能的重组 脑梗死后皮质的变化及康复治疗的影响 关于重组的程度和时间进程的再培训程序， 运动功能恢复运动地图将比较之前和不久 在局灶性血管梗塞之后。将讨论四个具体目标。要求1 将审查恢复期间行动模式的变化， 发生在完整运动皮层的神经生理学变化。本研究 应该阐明运动恢复是否是 重新学习中风前使用的运动模式，或者是学习的结果 新颖的补偿性运动模式目标2将评估 不同的康复训练方案，以优化运动恢复后， 中风虽然许多康复程序目前用于人类 中风患者，这项研究可以确定程序，产生最佳的 运动皮层的功能重组和最佳运动恢复。目的 3将检查重复的手工技能训练对运动地图的影响 和大面积缺血性梗死后的运动恢复。以前的研究使用 该猴子模型使用非常小的梗塞。不知道是否重复 当较大体积的皮层组织受伤时，训练是有效的。目的 4将检查延迟重复训练的有效性后， 中风培训程序将在一个月或三个月内推出 在大面积缺血性梗死后这项研究将确定是否有一个 开始康复训练的最佳时机， 最大化运动皮层的适应性可塑性以及运动恢复。 这些研究旨在提供临床理解， 脑卒中后的恢复过程以及 康复活动.神经生理重组与 脑损伤后的功能恢复可能最终导致新的方法 康复医学

Description: The long-term goals of this project are to examine the neural bases for recovery of motor function after a stroke and the effectiveness of rehabilitative training regimens on neurophysiologic and behavioral outcomes. These studies will use neurophysiologic and behavioral training techniques in adult primates to examine functional reorganization in the primary motor cortex after focal vascular infarct and the effects of rehabilitative retraining procedures on the extent and time course of reorganization and on functional motor recovery. Motor maps will be compared before and shortly after focal vascular infarct. Four specific aims will be addressed. Aim 1 will examine alterations in movement patterns during the recovery period and neurophysiologic changes that occur in the intact motor cortex. This study should shed light on the question of whether motor recovery is the result of relearning motor patterns used prior to stroke, or is the result of learning novel, compensatory motor patterns. Aim 2 will assess the effectiveness of different rehabilitative training regimens to optimize motor recovery after stroke. While many rehabilitative procedures are currently used in human stroke patients, this study could identify procedures which produce optimal functional reorganization in the motor cortex and optimal motor recovery. Aim 3 will examine the effects of repetitive manual skill training on motor maps and motor recovery following large ischemic infarcts. Previous studies using this monkey model used very small infarcts. It is not known if repetitive training is effective when a larger volume of cortical tissue is injured. Aim 4 will examine the effectiveness of delayed repetitive training after a stroke. Training procedures will be introduced either one or three months after a large ischemic infarct. This study will determine if there is an optimal window of opportunity to begin rehabilitative training in order to maximize adaptive plasticity in the motor cortex as well as motor recovery. These studies are designed to provide a clinical understanding for the recovery process after a stroke and the neurophysiologic effects of rehabilitation. The correlation of neurophysiologic reorganization with functional recovery after brain damage could eventually lead to new approaches to rehabilitative medicine.